%0 Journal Article
%T 近红外光谱技术用于六味地黄丸浓缩液质量的快速评价<br>Rapid Quality Evaluation of the Concentrated Liquid of Liuwei Dihuang Pills by Near-Infrared Spectroscopy
%A 常静
%A 马明
%A 孙达
%J Hans Journal of Medicinal Chemistry
%P 1-6
%@ 2331-8295
%D 2023
%I Hans Publishing
%R 10.12677/HJMCe.2023.111001
%X 目的：采用近红外光谱技术对六味地黄丸浓缩液中马钱苷、芍药苷、苯甲酰芍药苷的含量建立一种快速无损检测方法。方法：利用近红外光谱仪对六味地黄丸浓缩液样品进行扫描，对其光谱进行预处理和波段选择，并通过偏最小二乘法(Partial Least Squares, PLS)建立马钱苷、芍药苷、苯甲酰芍药苷含量快速无损检测方法。结果：所建模型的决定系数R分别为0.9921、0.9941、0.9927，RMSEP分别为0.0534、0.0491、0.0241，表明实验建立的近红外定量模型性能较好，且模型预测的样品值与其实际理化值无显著差异(P &gt; 0.05)。结论：本实验所建立的近红外定量模型能够较好地对六味地黄丸浓缩液中马钱苷、芍药苷、苯甲酰芍药苷的含量进行检测，表明近红外光谱技术适用于六味地黄丸浓缩液的快速无损检测。<br />
Objective: A rapid and nondestructive testing method of the contents of loganin, paeoniflorin and benzoyl paeoniflorin in the concentrated liquid of Liuwei Dihuang pills was established by the near-infrared spectroscopy. Methods: The sample of the concentrated liquid of Liuwei Dihuang pills was scanned by near-infrared spectrometer, its spectrum was preprocessed and band selection was carried out. Combined with Partial Least Squares (PLS) method, a rapid nondestructive testing method for the content of loganin, paeoniflorin and benzoyl paeoniflorin was established. Results: The determination coefficients R of the established model were 0.9921, 0.9941, 0.9927, and RMSEP were 0.0534, 0.0491, 0.0241, respectively, indicating that the NIR quantitative model established in the experiment had a good performance, and there was no significant difference between the sample values predicted by the model and the actual physical and chemical values (P &gt; 0.05). Conclusion: The near-infrared quantitative model established in this experiment can be used to detect the contents of loganin, paeoniflorin and benzoyl paeoniflorin in the concentrated liquid of Liuwei Dihuang pills, indicating that the near-infrared spectroscopy technology is suitable for rapid and nondestructive testing of the concentrated liquid of Liuwei Dihuang pills.
%K 六味地黄丸，浓缩液，马钱苷，芍药苷，苯甲酰芍药苷，近红外光谱技术，偏最小二乘法<br>Liuwei Dihuang Pills
%K Concentrated Liquid
%K Loganin
%K Paeoniflorin
%K Benzoyl Paeoniflorin
%K Near-Infrared Spectroscopy
%K Partial Least Squares Method
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=61425