%0 Journal Article
%T <sup>13</sup>C-美沙西丁的制备研究进展<br>Research Progress in the Preparation of <sup>13</sup>C-Methacetin
%A 付国桢
%A 胡石林
%A 曾静
%A 叶一鸣
%J Hans Journal of Medicinal Chemistry
%P 24-34
%@ 2331-8295
%D 2023
%I Hans Publishing
%R 10.12677/HJMCe.2023.111005
%X 目的：为<sup>13</sup>C-美沙西丁的合成方法进行总结并提供参考。方法：本文通过查阅相关文献，系统归纳了<sup>13</sup>C-美沙西丁各种合成方法在安全性、产率、经济性、工艺复杂程度等方面的优缺点。结果与结论：<sup>13</sup>C-美沙西丁现有的制备方式多为用<sup>13</sup>C-碘甲烷、<sup>13</sup>C-甲醇、<sup>13</sup>C-硫酸二甲酯等甲基化试剂与对乙酰氨基酚反应获得。采用Mitsunobu醚化反应制备<sup>13</sup>C-美沙西丁，反应物毒性低、产率和纯度较高、反应流程比较简单，是一种合适的方法，有着广阔的发展前景。<br />
Objective: To summarize and provide a reference for the synthetic methods of <sup>13</sup>C-Methacetin. Methods: This paper systematically summarized the advantages and disadvantages of various synthetic methods of <sup>13</sup>C-Methacetin in terms of safety, yield, economy, process complexity, etc. Results and Conclusion: The existing methods of preparation of <sup>13</sup>C-Methacetin are mostly obtained by reaction of <sup>13</sup>C-iodomethane, <sup>13</sup>C-methanol, <sup>13</sup>C-dimethyl sulfate and other methylating agents with acetaminophen. Using Mitsunobu etherification reaction to prepare <sup>13</sup>C-Methacetin is a suitable method with low toxicity, high yield and purity of reactants, and simple reaction process. It is an appropriate method and has broad development prospects.
%K <sup>13</sup>C-美沙西丁，肝功能检测，合成方法<br><sup>13</sup>C-Methacetin
%K Liver Function Test
%K Synthetic Method
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=61981