%0 Journal Article
%T NLRP3 Inflammasome in Relation to Glucose and Lipid Metabolism, and Insulin Resistance in Diabetes and Pre-Diabetes
%A Shujuan Hu
%A Dang Liu
%A Yinqi Zhang
%A Yiting Ding
%A Bingqing Li
%A Xianwang Wang
%J Yangtze Medicine
%P 1-10
%@ ****-****
%D 2023
%I Scientific Research Publishing
%R 10.4236/ym.2023.71001
%X <strong>Aims:</strong> To investigate the relationship among NLRP3 inflammasome, glucose and lipid metabolism, and insulin resistance (IR) in the serum of patients with diabetes and pre-diabetes. <strong>Methods:</strong> A total of 100 patients with abnormal blood glucose divided into the pre-diabetes mellitus (PDM) group (N = 46) and the type 2 diabetes mellitus (T2DM) group (N = 54). 20 normoglycemic subjects (NG, N = 20) were selected as a control group. The serum levels of glucose and lipid metabolism, IR, and the expression of NLRP3, ASC and Caspase-1 were measured. Besides, the correlations of NLRP3 inflammasome with glucose and lipid metabolism, and IR were analyzed. <strong>Results:</strong> Compared with the NG group, the levels of NLRP3, ASC, Caspase-1, FBG, HbA<sub>1</sub>C, TG, LDL-C, FINs, and HOMA-IR were higher (<em>P</em> &lt; 0.05), while the contents of HDL-C and HOMA-<em>¦Â</em> were lower (<em>P</em> &lt; 0.05) in the serum of both PDM and T2DM groups. Elevated levels of NLRP3, ASC, Caspase-1, FBG, HbA<sub>1</sub>C, FINs, and HOMA-IR were detected (<em>P</em> &lt; 0.05), while decreased contents of HDL-C and HOMA-<em>¦Â</em> were seen (<em>P</em> &lt; 0.05) in T2DM group when compared with those in the PDM group. Correlation analysis found that activation of NLRP3 inflammasome was positively correlated with the concentrations of HbA<sub>1</sub>C, FINs, and HOMA-IR (<em>P</em> &lt; 0.05), but negatively correlated with HDL-C and HOMA-<em>¦Â</em>. Regression analysis further showed that blood glucose related indexes, FINs, and NLRP3 have made a decisive contribution to IR. <strong>Conclusions:</strong> Collectively, this evidence suggested that NLRP3 is closely related to glucose and lipid metabolism, and IR, and activated in PDM and T2DM.
%K Type 2 Diabetes Mellitus
%K Pre-Diabetes Mellitus
%K NLRP3
%K Glucose and Lipid Metabolism
%K Insulin Resistance
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=123558