%0 Journal Article
%T 亚慢性氟中毒致小鼠脑损伤的作用及机制研究<br> Study on the Role and Mechanism of Subchronic Fluorosis Induced Brain Injury in Mice
%A 裘林晨
%J Bioprocess
%P 19-26
%@ 2164-5582
%D 2023
%I Hans Publishing
%R 10.12677/BP.2023.131003
%X 氟对人体有双重作用，氟是人体所需的微量元素，但是一旦过量就会造成氟中毒。地方性氟中毒是指人们在生活中摄入过量的氟而导致的全身性蓄积性中毒。地方性氟中毒作为一种病因清楚但机理未明的疾病，一直得到国内外的广泛关注。自由基损伤学说是其中一种比较公认的学说，但这几年钙矛盾学说逐渐成为研究热点。Ca<sup>2+</sup>是神经细胞内一种重要的信息分子，L-型钙离子通道在调节胞质内Ca<sup>2+</sup>的水平中发挥重要作用，通过探讨L型钙离子通道在氟致脑影响的作用研究，从分子水平完善氟中毒致氧自由基损伤学说和钙矛盾疾病学说，进一步探讨氟致脑损伤的发病机制，为防治氟致脑损伤提供新途径和新方法。<br />
Fluoride has a dual effect on the human body. Fluoride is a trace element needed by the human body, but once it is excessive, it will cause fluorosis. Endemic fluoro-sis refers to the systemic cumulative poisoning caused by excessive intake of fluorine in People’s Daily life. Endemic fluorosis, as a disease with clear etiology but unknown mechanism, has been widely concerned at home and abroad. The theory of free radical damage is one of the more recog-nized theories, but the calcium paradox theory has gradually become a research hotspot in recent years. Ca<sup>2+</sup> is an important information molecule in nerve cells, and L-type calcium channel plays an important role in regulating the level of cytosolic Ca<sup>2+</sup>. By exploring the role of L-type calcium channel in the influence of fluorosis on the brain, we improve the theory of oxygen free radical damage caused by fluorosis and the theory of calcium contradiction disease from the molecular level, and further explore the pathogenesis of brain damage caused by fluorosis. It provides a new way and method for the prevention and treatment of brain injury caused by fluoride.
%K 氟中毒，脑损伤，细胞凋亡，L型钙离子通道<br> Fluorosis
%K Brain Injuries
%K Apoptosis
%K L-Type Calcium Channels
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=62184