%0 Journal Article
%T Anti-Biofilm, Anti-Quorum Sensing, and Anti-Proliferative Activities of Methanolic and Aqueous Roots Extracts of <i>Carica papaya</i> L. and <i>Cocos nucifera</i> L.
%A Wendkouni Leila Marie Esther Belem-Kabr¨¦
%A Vincent Ou¨¦draogo
%A Bagora Bayala
%A Alimata Banc¨¦
%A Estelle Ou¨¦draogo
%A Boubacar Yaro
%A Lazare Belemnaba
%A Moussa Compaor¨¦
%A Martin Kiendr¨¦beogo
%A Noufou Ou¨¦draogo
%J Advances in Microbiology
%P 165-180
%@ 2165-3410
%D 2023
%I Scientific Research Publishing
%R 10.4236/aim.2023.134010
%X <b>Objective:</b> This study focused on the antibacterial and anti-proliferative activity of extracts from <i>Carica papaya</i> and <i>Cocos nucifera</i> roots. <b>Methodology:</b> The minimum inhibitory concentration and the minimum bactericidal concentration of the extracts on <i>Escherichia coli</i>, <i>Pseudomonas aeruginosa</i>, <i>Streptococcus mutans</i>, and <i>Staphylococcus aureus</i> were deduced by the microdilution method. The anti-biofilm activity was determined on all four strains and anti-quorum sensing activity by inhibition of violacein production in <i>Chromobacterium violaceum</i>. Anti-proliferative activity on prostate cultured cancer cells was evaluated by MTT assay. Sterols and triterpenes were also assayed in this study. <b>Results:</b> The methanolic extract of <i>Carica papaya</i> showed the best anti-biofilm effect with a percentage inhibition of 66.10 ¡À 1.79. The methanolic extract of <i>Cocos nucifera</i> had the strongest inhibition on the production of quorum sensing (61.42 ¡À 0.28). In addition, the methanolic extract of <i>Cocos nucifera</i> roots showed the best cytotoxic effect on prostate cancer LNCaP cell lines (IC<sub>50</sub> = 26.98 ¡À 2.6 ¦Ìg/mL) and <i>Carica papaya</i> on the PC-3 lines (IC<sub>50</sub> = 127.20 ¡À 5.99 ¦Ìg/mL). The extracts were also rich in triterpenes and sterols. <b>Conclusion:</b> This study provides support for the ethnomedical use of <i>Carica papaya</i> and <i>Cocos nucifera</i> roots as an antimicrobial and anticancer.
%K Triterpenes and Sterols Content
%K Antibacterial
%K Biofilm
%K Quorum Sensing
%K Anti-Proliferative
%K Medicinal Plants
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=124194