%0 Journal Article
%T Clinicopathologic Characteristics of Differentiated Thyroid Carcinoma in Children and Adolescents
%A Tianzhi Zhang
%A Chao Liang
%A Guangchang Shan
%A Danting Su
%J Advances in Bioscience and Biotechnology
%P 143-150
%@ 2156-8502
%D 2023
%I Scientific Research Publishing
%R 10.4236/abb.2023.144009
%X <b><span style=\"font-family:&quot;\">Objective: </span></b><span style=\"font-family:&quot;\">To
investigate the clinicopathologic features of differentiated thyroid carcinoma
in children and adolescents. </span><b><span style=\"font-family:&quot;\">Methods:</span></b><span style=\"font-family:&quot;\"> The
clinical data of 7 children and adolescents with differentiated thyroid
carcinoma were retrospectively analyzed, and the clinicopathologic features of
differentiated thyroid carcinoma were analyzed by gender, tumor size and BRAF
mutation. </span><b><span style=\"font-family:&quot;\">Results:</span></b><span style=\"font-family:&quot;\"> There were 7 cases of thyroid papillary carcinoma. The
mean age of patients was (18.71 ¡À 2.75), and the mean tumor diameter was (2.4 ¡À
1.04) cm. Lymph node metastasis rate was 100% (7/7). In children and
adolescents, the lesion volume was larger, membrane invasion and vascular
cancer thrombus were more likely to occur, BRAF mutation was less common, and
the difference was statistically significant. </span><b><span style=\"font-family:&quot;\">Conclusion:</span></b><span style=\"font-family:&quot;\"> Children
and adolescents with differentiated thyroid carcinoma are more aggressive and
prone to membrane invasion and lymph node metastasis; BRAF mutation is less
common than in adults.
%K Children and Adolescents
%K Thyroid Papillary Carcinoma
%K Clinicopathological Features
%K BRAF Mutation
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=124349