%0 Journal Article
%T 低银杏酚酸白果粉脱毒工艺优化<br>Optimization of Detoxification Process for Low Ginkgo Phenolic Acid in Ginkgo Powder
%A 康津铭
%A 王云春
%A 樊恩生
%A 刘鹏程
%A 吴泽宇
%A 惠爱玲
%A 张文成
%J Hans Journal of Medicinal Chemistry
%P 41-49
%@ 2331-8295
%D 2023
%I Hans Publishing
%R 10.12677/HJMCe.2023.112007
%X 本文采用正己烷–乙醇混合溶剂降低银杏酚酸含量，建立一种低酚酸白果粉的工艺。作者探究了正己烷浓度、洗脱时间、洗脱温度单因素影响，并进一步通过响应面法优选出工艺参数：正己烷含量为16.69%，洗脱温度为41.73℃，洗脱时间为28.02 min，此条件下银杏酸含量 &lt; 10 mg/kg，符合国家药典2020版标准。<br />
In this paper, n-hexane-ethanol mixed solvent was used to reduce the content of ginkgo phenolic acid, and a process design optimization idea for ginkgo powder with low phenolic acid was established. In the experiment of reducing phenolic acid content, the n-hexane concentration, elution time and elution temperature were investigated respectively. The optimal conditions for removing phenolic acid are obtained by response surface methodology: n-hexane content is 16.69%, the elution temperature is 41.73？C, and the elution time is 28.02 min. Under this condition, the phenolic acid content is less than 10 mg/kg, which meets national pharmacopoeia 2020.
%K 白果粉，银杏酚酸，工艺优化<br>Ginkgo Powder
%K Ginkgolic Acid
%K Technology Optimization
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=65001