%0 Journal Article
%T Evolution of Acquired Humoral Immunity after Full Vaccination against SARS-CoV-2. IgG Levels in Healthcare Workers at 6 and 9 Months
%A Victoria Delicado-Useros
%A Esther Navarro-Rodenas
%A Indalecio-M S¨¢nchez-Onrubia
%A Carmen Ortega-Mart¨ªnez
%A Antonia Alfaro-Esp¨ªn
%A Juan-D P¨¦rez-Serra
%A Francisco Garc¨ªa-Alcaraz
%A Julia Lozano-Serra
%A Lorena Robles-Fonseca
%A Teresa P¨¦rez-Domenech
%J World Journal of Vaccines
%P 13-32
%@ 2160-5823
%D 2023
%I Scientific Research Publishing
%R 10.4236/wjv.2023.132002
%X <strong>Background:</strong> The COVID-19 pandemic continues to be a major worldwide health problem. The present study aims to contribute to surveillance of the immune and clinical response of vaccines to SARS-CoV-2. <strong>Methods:</strong> Observational medication study on acquired immunity and effectiveness of vaccines. Population: 620 workers in the health service of Almansa (Spain). Representative sample of 150 individuals. Sociodemographic, clinical, and epidemiological data and samples were recorded to determine anti-SARS-CoV-2 serum IgG levels 6 and 9 months after vaccination with Pfizer. <strong>Results: </strong>Mean age 46.45 years; 76% women; 85.1% working in a hospital. 19.3% had had COVID-19 in the year prior to vaccination. 96.7% were fully vaccinated with Pfizer/BioNTech. At 6 months, 100% seropositivity and mean IgG levels of 3017.2 AU/ml. Significant variations in IgG levels in individuals with prior COVID-19 infection and smokers. At 9 months, 99.3% remained seropositive; 2.8% infected after vaccination. The repeated measures analysis showed a difference in means of 669.0 AU/ml (significant decrease in IgG levels of 28.9%). <strong>Conclusion:</strong> Antibody levels remained positive 6 and 9 months after vaccination, although IgG levels were found to decay.
%K Acquired Immunity
%K SARS-CoV-2 Vaccine
%K IgG level
%K Healthcare Workers
%K COVID-19 Incidence Rate
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=124880