%0 Journal Article
%T Review: Practical Use of a Neurophysiological Detector and the Protocol for High-Performance Liquid Chromatography
%A Ilia Brondz
%J International Journal of Analytical Mass Spectrometry and Chromatography
%P 1-10
%@ 2332-1776
%D 2023
%I Scientific Research Publishing
%R 10.4236/ijamsc.2023.111001
%X The
main aim for discovery and development of the neurophysiological detector was
detection of the production¡¯ seats and <span><span><span style=\"font-family:;\" \"=\"\">criminal use of poisons in <span>warfare</span></span></span></span><span><span><span style=\"font-family:;\" \"=\"\">. Phosphor-organic (PO)
substances with acetylcholinesterase-blocki</span></span></span><span><span><span style=\"font-family:;\" \"=\"\">ng effects are prohibited in warfare by international law (Geneva
Protocol. </span></span></span><span><span><span style=\"font-family:;\" \"=\"\"><br />
</span></span></span><span><span><span style=\"font-family:;\" \"=\"\"><a href=\"#ref12\">https://www.un.org/disarmament/wmd/bio/1925-geneva-protocol/</a></span></span></span><span><span><u><span style=\"font-family:;\" \"=\"\">)</span></u></span></span><span><span><span style=\"font-family:;\" \"=\"\">.</span></span></span><span><span><span style=\"font-family:;\" \"=\"\"> Monitoring PO analogs with acetylcholinesterase-blocking
effects and their degradation products in water and soil can provide clues to
unlawful production sites and the possible use of POs in warfare. Attempts to
analyze POs by derivatization have had a low ability to detect them. A
neurophysiological detector (NPD)-high-performance liquid chromatography (HPLC)
system was developed for specific detection with high detection ability. The
first official presentation of our NPD was at the <span>3<sup>rd</sup><i> International Symposium on Separation in BioSciences
SBS </i>2003:<i> A </i>100 <i>Years of Chromatography</i></span>, May 13</span></span></span><span><span><span style=\"font-family:;\" \"=\"\">-</span></span></span><span><span><span style=\"font-family:;\" \"=\"\">18,
2003, in Moscow, Russia.</span></span></span><span><span><span style=\"font-family:;\" \"=\"\"> </span></span></span><span><span><span style=\"font-family:;\" \"=\"\">The NPD in connection to HPLC was developed 14 years before the
presentation at the SBS in 2003. Initially, NPD combined with an HPLC system
was developed for intelligence services and only for use in monitoring and
espionage against the unlawful production of neuroparalytic agents, as
explained in this article. NPD combined with an HPLC system was developed in
Ume&#229;, Sweden, in 1987</span></span></span><span><span><span style=\"font-family:;\" \"=\"\">-</span></span></span><span><span><span style=\"font-family:;\" \"=\"\">89; the protocol was further developed in Statens Plantevern Institutt,
&#197;s, Norway, in 1990</span></span></span><span><span><span
%K Neurophysiological Detector
%K Phosphor-Organic Substances
%K Tabun
%K Soman
%K Criminal Use of Poisons in Warfare
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=125104