%0 Journal Article
%T 南药牛大力标准汤剂质量差异性分析<br>Quality Difference Analysis of Standard Decoction of Millettia speciosa Champ
%A 申亚君
%A 高晗
%A 姜国志
%A 李军山
%J Hans Journal of Medicinal Chemistry
%P 93-99
%@ 2331-8295
%D 2023
%I Hans Publishing
%R 10.12677/HJMCe.2023.112012
%X 目的：建立牛大力标准汤剂质量评价方法，比较不同产地牛大力标准汤剂的差异性。方法：制备12批不同产地牛大力标准汤剂，测定出膏率，建立牛大力标准汤剂HPLC指纹图谱及对指标性成分刺桐碱含量测定，并结合化学计量学方法对12批牛大力标准汤剂差异性进行分析。结果：建立了牛大力标准汤剂指纹图谱，确定了5个共有峰，指认了一个共有峰。主成分分析(PCA)将样品分为4类，正交偏最小二乘法判别分析(OPLS-DA)找出了两个差异性化合物，分别为峰3、峰5 (刺桐碱)。不同产地刺桐碱含量测定平均值分别为：3.175 mg/g、11.572 mg/g、1.586 mg/g、3.873 mg/g。本文所建立的牛大力标准汤剂质量评价方法科学有效，可用于牛大力的质量控制和评价。<br />
Objective: To establish an analysis method of the quality evaluation method and investigate the quality differences of Millettia speciosa Champ (MSC) standard decoctions from different habitats. Methods: Twelve batches of MSC standard decoction were prepared. The extract rates, the yield of Hypaphorine were determined. Chromatographic fingerprints of MSC standard decoctions were generated from HPLC and the quality differences were analyzed using the method of chemometrics and statistics. Conclusion: The fingerprints of the MSC standard decoctions were established a total of 5 common peaks were determined respectively, and one peak was identified. MSC standard decoctions sample was dividedinto four groups by PCA, then two marker compounds were selected and identified by OPLS-DA, including peaks-3, peaks-5 (Hypaphorine). The average content of Hypaphorine from different habitats was 3.175 mg/g, 11.572 mg/g, 1.586 mg/g, 3.873 mg/g. A scientific and effective evaluation method of MSC standard decoction was established, which also provided a reference for the identification and quality control of MSC.
%K 牛大力，标准汤剂，刺桐碱<br>Millettia speciosa Champ
%K Standard Decoction
%K Hypaphorine
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=66007