%0 Journal Article
%T 组蛋白去乙酰化酶抑制剂的研究进展<br>Research Progress on Histone Deacetylase Inhibitors
%A 汤玉姜
%A 周庆发
%J Hans Journal of Medicinal Chemistry
%P 116-126
%@ 2331-8295
%D 2023
%I Hans Publishing
%R 10.12677/HJMCe.2023.112015
%X 组蛋白去乙酰化酶于上世纪90年代发现，其在氨基酸侧链的翻译后修饰起到重要作用，并且广泛在肿瘤细胞中高度表达。因此，研究开发新型的组蛋白去乙酰化酶抑制剂可以有效靶向针对肿瘤细胞。30多年来，人们对组蛋白去乙酰化酶的认识愈加清晰，并在这些认识的基础上创造了许多针对不同癌症的小分子药物。本文综述了目前临床上对组蛋白去乙酰化酶抑制剂的研究，并分类介绍其研究进展，希望能对后续组蛋白去乙酰化酶的抑制剂开发有所帮助。<br />
Histone deacetylase was discovered in the 90s of last century which plays an important role in the post-translational modification of side chains, and was widely expressed in tumor cells. Therefore, researching and developing novel histone deacetylase inhibitors can effectively target tumor cells. Over the past 30 years, people’s understanding of histone deacetylase had become increasingly clear, and many small molecule drugs for different cancers was created on the basis of these understandings. This article reviews the current clinical research on histone deacetylase inhibitors and categorizes their progress, hoping to be helpful for the subsequent development of histone deacetylase inhibitors.
%K 组蛋白去乙酰化酶，临床进展，癌症<br>Histone Deacetylase
%K Clinical Research
%K Cancer
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=66258