%0 Journal Article
%T Potential Application of a Wine Extract in Skin Care: How to Benefit from the Antibacterial, Antioxidant and Elastase Inhibiting Properties
%A Lisa-Marie Sittek
%A Thomas Michael Schmidts
%A Peggy Schlupp
%J Journal of Cosmetics, Dermatological Sciences and Applications
%P 136-155
%@ 2161-4512
%D 2023
%I Scientific Research Publishing
%R 10.4236/jcdsa.2023.132013
%X Since plant polyphenols have many beneficial properties on health, the aim of this study was to evaluate the potential use of a phenolic wine extract, a by-product of wine production, for skin care on HaCaT cells. In these studies, a significant reduction of reactive oxygen species formation in HaCaT cells and severe elastase inhibition was observed. In contrast, the wine extract caused a major increase in lipase activity. The extract showed no influence on cell proliferation, but an immunomodulatory effect on the release of the interleukins IL-6 and IL-8 was found. The phenolic wine extract demonstrated a strong activity against gram-positive and gram-negative pathogens, yeasts, and fungi. Overall, our results show that the investigated phenolic wine extract is a promising ingredient for anti-aging skin care, could contribute to the improvement of skin appearance and health, and may positively affect cellulite.
%K Phenolic Wine Extract
%K Skin Care
%K HaCaT Cells
%K Elastase
%K Lipase
%K IL-6
%K IL-8
%K Cell Proliferation
%K Reactive Oxygen Species
%K Antimicrobial
%K Antimycotic
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=125663