%0 Journal Article
%T Tumor Local Microenvironment Is a Key Factor Affecting the Efficacy of PD-1 Inhibitor in Advanced Cervical Cancer: A Case Report and Literature Review
%A Mamady Keita
%A Xi Chen
%A Shiguan Wang
%A Yakun Liu
%A Jing Ma
%A Traor¨¦ Bangaly
%A Hong Liu
%J Journal of Cancer Therapy
%P 299-305
%@ 2151-1942
%D 2023
%I Scientific Research Publishing
%R 10.4236/jct.2023.146025
%X <strong>Introduction:</strong><span><span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\"> Conventional radiotherapy or chemotherapy is
ineffective in </span><span style=\"font-family:Verdana;\">the treatment of recurrent
and metastatic cervical cancer. In recent years, immunotherapy </span><span style=\"font-family:Verdana;\">has shown
promise in the treatment of various solid tu</span><span style=\"font-family:Verdana;\">mours,
including cervical cancer. The overall response rate of the PD-1/PD-L1</span><span style=\"font-family:Verdana;\"> inhibitor in cervical cancer is 14</span></span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">% </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">-</span></span></span><span><span><span style=\"font-family:&quot;\"> </span></span></span><span><span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">27%, and when combined with radiotherapy or </span><span style=\"font-family:Verdana;\">conventional chemotherapy, the overall response
rate can be further improved.</span> <b><span style=\"font-family:Verdana;\">Case presentation:</span></b><span style=\"font-family:Verdana;\"> We report here a
case of a 49-year-old female patient presenting with two metastatic lesions of
cervical cancer after postoperative radiotherapy, the first was located in the
para-aortic region and the second in the presacral region. The enlarged
para-aortic lymph nodes had not previ</span><span style=\"font-family:Verdana;\">ously
received radiotherapy, while the enlarged presacral lymph nodes had previously
received postoperative radiotherapy. Treatment results showed that the
recurrent presacral mass did not respond to the PD-1 inhibitor (camrelizumab) </span><span style=\"font-family:Verdana;\">alone,
whereas the metastatic para-aortic lymph nodes responded favourably to
camrelizumab combined with low-intensity radiotherapy.</span></span></span></span><span><span><span style=\"font-family:&quot;\"> </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><b><span style=\"font-family:Verdana;\">Conclusion:</span></b></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"> PD1/PD-L1 inhibitors combined with radiotherapy
should make it possible to overcome the bottleneck of conventional
radiotherapy, improve patient prognosis or achieve
%K Cervical Cancer
%K PD-1 Inhibitor
%K Recurrence and Metastasis
%K Radiotherapy
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=125902