%0 Journal Article
%T Propensity for Progressive Renal Disease in Nephroangiosclerosis: A Refractory Phenotype of Genetic Vasculopathy in Essential Hypertension
%A Kamel El-Reshaid
%A Shaikha Al-Bader
%A John Madda
%J Open Journal of Nephrology
%P 220-225
%@ 2164-2869
%D 2023
%I Scientific Research Publishing
%R 10.4236/ojneph.2023.133021
%X <strong>Background:</strong> Inadequate treatment of essential hypertension (EH), Obesity, smoking, carbohydrate intolerance, hyperlipidemia, and nephrotox-in-exposure are major confounding factors in progression of Nephroangiosclerosis (N). However, neither the prevalence nor the severity of EH is a reliable predictor of individuals at risk for subsequent nephropathy. <strong>Patients and Methods:</strong> A 10-years retrospective analysis of 165 adequately treated patients with EH. <strong>Results: </strong>We observed 2 different renal outcomes. Twenty-three (14%) patients manifested progressive renal disease with &gt; doubling serum creatinine and proteinuria with 3 reaching end-stage kidney disease. At start, biopsy of those patients showed features of ”°benign”± nephroangiosclerosis (N) ”Ą secondary form of focal and segmental glomerulosclerosis (without immune deposits). On the other hand; 142 with similar demographic characteristics, duration and severity of disease did not show significant renal disease on follow up. <strong>Conclusion:</strong> Induction of progressive N, in patients with EH, is compatible with phenotypic susceptibilities of genetic disorders.
%K Biopsy
%K Kidney Disease
%K Genetics
%K Hypertension
%K Outcome
%K Nephroangiosclerosis
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=127340