%0 Journal Article
%T Audit of the Physico-Chemical Quality of Amoxicillin Based Drugs Marketed in Senegal
%A Coulibaly Dalan¨¦ Bernadette
%A Sow Fatoumata Tata
%A Naco Mohamed El B¨¦chir
%A N¡¯Diaye Mahamar
%A Toure Hamadoun Abba
%A Mariko Madani
%A Dackouo Blaise
%A Diouf Di¨¦ry
%A Koumare Benoit Yaranga
%A Sarr Serigne Omar
%J American Journal of Analytical Chemistry
%P 351-361
%@ 2156-8278
%D 2023
%I Scientific Research Publishing
%R 10.4236/ajac.2023.149019
%X Non-compliant antibiotics pose problems of therapeutic efficacy at the level of the individual, but also a serious public health problem. The objective of our study was to evaluate the quality of generic amoxicillin (42 samples) by analytical methods in Dakar/Senegal. At 100% visual inspection of compliance; 100% compliance uniformity test; at the dissolution test all > 80% (86.8% to 108.8%). The presence of amoxicillin with the following contents: Tablets (95.2% to 104.1%); Capsules (91.5% to 113.9%) and Suspensions drinkable (96.9% - 118.7%). All the samples in our study are 100% compliant according to the European and American pharmacopoeias (90% - 120%). Other studies should therefore be oriented in the direction of stability as well as the dosage of degradation products.
%K Quality Control
%K Amoxicillin
%K Analytical Methods
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=127847