%0 Journal Article
%T P-糖蛋白在肿瘤中的研究新进展<br>New Research Progress of P-Glycoprotein in Tumor
%A 邹青
%A 吕圆
%J World Journal of Cancer Research
%P 155-163
%@ 2164-9057
%D 2023
%I Hans Publishing
%R 10.12677/WJCR.2023.134022
%X P-糖蛋白是一种位于细胞膜上，对疏水性及两性化合物具有特异性的一类转运蛋白。在生理条件下，P-糖蛋白分布在机体内多种组织、器官中，在药物的吸收、分布、代谢及排泄过程中都发挥着重要的作用。P-糖蛋白广泛存在于各种肿瘤细胞，与其发展密切相关。P-糖蛋白可加速机体抗癌药物产生耐药，调控P-糖蛋白水平可以调控肿瘤的发展和减少肿瘤药物耐药性。<br />
P-glycoprotein is a kind of transporter which is located on the cell membrane and has specificity for hydrophobic and amphoteric compounds. Under physiological conditions, P-glycoprotein is distributed in various tissues and organs in the body, and plays an important role in the absorption, distribution, metabolism and excretion of drugs. P-glycoprotein exists widely in various tumor cells and is closely related to its development. P-glycoprotein can accelerate anti-cancer drug resistance in the body, and regulate P-glycoprotein level which can regulate tumor development and reduce drug resistance.
%K P-糖蛋白，肿瘤，药物<br>P-Glycoprotein
%K Tumor
%K Drug
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=73565