%0 Journal Article
%T 超声辅助碱液脱除白果中银杏酚酸工艺优化<br>Technology Optimization of Removing Ginkgolic Acid from Ginkgo biloba by Ultrasound Assisting Alkaline Solution
%A 龚君豪
%A 修效友
%A 徐涛
%A 惠爱玲
%A 吴泽宇
%A 张文成
%J Hans Journal of Medicinal Chemistry
%P 242-249
%@ 2331-8295
%D 2023
%I Hans Publishing
%R 10.12677/HJMCe.2023.114029
%X 本文采用固定功率超声辅助碱液降低白果中银杏酚酸的含量，建立一种降低白果粉中银杏酚酸类致敏物质的新工艺。作者探究了萃取时间、萃取温度、碱液中甘油添加量的单因素影响，并进一步通过正交法优选出工艺参数：超声萃取时间40 min、萃取温度40℃、碱液中甘油添加量15‰，此条件下银杏酚酸含量为1.35 μg/ml，符合国家药典2020版标准。<br />
In this paper, fixed power ultrasound assisting alkaline solution was used to reduce the content of ginkgolic acid in Ginkgo biloba and establish a new process for reducing the allergenic substances of ginkgolic acid in Ginkgo biloba powder. The authors explored the single-factor effects of extraction time, extraction temperature, and the amount of glycerol added to the alkaline solution, and further optimized the process parameters through orthogonal design: extraction time of 40 minutes, ex-traction temperature of 40？C and the amount of glycerol added to the alkaline solution of 15‰. Under this condition, the ginkgolic acid content is 1.35 μg/ml, which meets the standard of the National Pharmacopoeia 2020 edition.
%K 超声辅助，白果，银杏酚酸，工艺优化<br>Ultrasound Assisting
%K Ginkgo biloba
%K Ginkgolic Acid
%K Technology Optimization
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=75286