%0 Journal Article %T Contribution to the Study of Antibiotic Sensitivity of <i>Streptococcus pneumoniae</i> Strains in Spinal Cerebral Fluids in Bangui from 2017 to 2022 %A Z¨¦phirin-Dalengat Vogbia %A Ernest Lango Yaya %A Marie Colette-Nganda Banguet %A Jean de Dieu Longo %A Clotaire -Rafa£¿ %A Maurel Anicet Adonis Ouoko Fa-Tigbia %A Christian Diamant Mossoro %A G¨¦rard Gresenguet %J Journal of Biomedical Science and Engineering %P 95-106 %@ 1937-688X %D 2023 %I Scientific Research Publishing %R 10.4236/jbise.2023.167007 %X
A prospective and analytical study was carried out from January 2017 to Decem-ber 2022, at the National Laboratory of Clinical Biology and Public Health (LNBCSP) in Bangui. 352 samples of cerebrospinal fluid (CSF) were confirmed out of 2065, coming from the four hospitals in Bangui. This study aimed to evalu-ate the evolution of antibiotic sensitivity to strains of Streptococcus pneumoniae. CSF had been collected from patients who presented with meningeal syndromes. Based on the leukocyte count (White blood cells ¡Ý 5 mm3), an aliquot was trans-ferred to trans-isolate medium and sent to the LNBCSP for confirmatory testing, culture and determination of antibiotic sensitivity. The antibiotic sensitivity of Streptococcus pneumoniae strains was tested according to the methods recom-mended by the Antibiogram Committee of the French Society of Microbiology. The data collected was entered into Excel 2010 to be analyzed with Epi Info 7.2. Ficher¡¯s exact test, chi2 at the 5% threshold (p < 0.05) was used to compare pro-portions and analyze associations between variables. The average sensitivity rate to ¦Â-lactams was 74.43%. The sensitivity rate of Fluoroquinolones was 54.54%. That of levofloxacin was 87%. The average rate of sensitivity to ¦Â-lactams for the age group under 5 years old was 79.25%. That of fluoroquinolones was 52.59%. Levofloxacin had 90.37%. The average sensitivity rate to ¦Â-lactams for the age group over 5 years old was 76.03%. Fluoroquinolones had 45.16%. Levofloxacin had 69.58%. The average sensitivity rate to ¦Â-lactams for males was 76.68%. Fluoroquinolones had 54.26%. That of levofloxacin was 83.40%. The sensitivity rate to ¦Â-lactams for females was 74.41%. That of fluoroquinolones was 51.16%. Levofloxacin had 67.44%. Cyclins had 28.68%. The study noted an association between age and sensitivity (p < 0.05; CI [1.05-2.57]). Strains of Streptococcus pneumoniae were always detected in the CSF. The average rate of sensitivity to macrolides was 36.93%; aminoglycosides 28.69%; phenicols 63.35%; sulfona-mides 39.2%. These results could suggest a reduced sensitivity to ¦Â lactams.