%0 Journal Article
%T Association between Hyperhomocysteinemia and Microangiopathic Complications (Neuropathy and Nephropathy) in Subjects with Type 1 and Type 2 Diabetes
%A Nene Oumou Kesso Barry
%A Soukeyna Gueye
%A Moustapha Djit¨¦
%A Pape Matar Kandji
%A Michel Assane Ndour
%A El Hadj Malick Ndour
%A Demba Diedhiou
%A Fatou Gueye-Tall
%A Ndeye Mareme Thioune
%A Najah Fatou Coly
%A Dominique Doupa
%A Ma£¿mouna Ndour Mbaye
%A Philom¨¨ne Lopez Sall
%A Papa Madieye Gueye
%J Journal of Diabetes Mellitus
%P 325-339
%@ 2160-5858
%D 2023
%I Scientific Research Publishing
%R 10.4236/jdm.2023.134024
%X This prospective case-control study aimed to assess the prevalence of hyperhomocysteinemia and explore its potential correlation with microangiopathic complications, specifically nephropathy and neuropathy, in a cohort of both type 1 and type 2 diabetic patients. Conducted at the Marc Sankal¨¦ Center of Abass Ndao Hospital in Dakar from June to September 2018, the study enrolled a total of 106 diabetic patients, comprising 93 type 2 diabetics and 13 type 1 diabetics, who were matched with control subjects free from clinically detectable pathologies, based on sex and age ¡À 2 years. The mean age of type 1 and type 2 diabetic patients was 24.46 ¡À 8.41 years and 57.28 ¡À 11.28 years, respectively. Our findings revealed a statistically significant elevation in mean homocysteine levels among patients when compared to controls (12.63 vs. 9.88; p < 0.0001). Hyperhomocysteinemia was observed in 24.5% of the patients, exclusively among those with type 2 diabetes. Within the hyperhomocysteinemia subgroup, 58% were male, and 42% were female. The analysis of neuropathy and nephropathy frequencies among type 2 diabetic patients, stratified by homocysteine concentrations, demonstrated a notably higher prevalence of diabetic nephropathy in patients with hyperhomocysteinemia compared to those with normohomocysteinemia (23.07% vs. 8.75%; p = 0.052). Similarly, diabetic neuropathy exhibited a significantly greater frequency in patients with hyperhomocysteinemia as opposed to normohomocysteinemia (80.76% vs. 50%; p = 0.005). Furthermore, our results established a significant positive correlation between homocysteine concentrations and both age (r = 0.402; p < 0.0001) and creatinine levels (r = 0.461; p < 0.0001). Bivariate logistic regression analysis indicated that patients with hyperhomocysteinemia faced 3 times and 6 times higher risks of developing neuropathy (OR = 3.5; p = 0.061) and diabetic nephropathy (OR = 6.092; p = 0.014), respectively.
%K Homocysteine
%K Hyperhomocysteinemia
%K Diabetes Mellitus
%K Type 1 Diabetes
%K Type 2 Diabetes
%K Nephropathy
%K Neuropathy
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=129490