%0 Journal Article
%T LC-MS Phytochemical Profiles of Phenolic Compounds and Antimicrobial, Antioxidant, and Antiplasmodial Activities of Ethanol Extracts of <i>Pycnostachys erici-rosenii</i> R.E.Fr and <i>Leucas martinicensis</i> (Jack.) R.Br (Lamiaceae)
%A Uwikunda Serondo H¨¦ritier
%A Nizigiyimana Lib¨¦rata
%A Pius Tshimankinda Mpiana
%A Nyamangyoku Ishibwela Obedi
%A Ngezahayo J¨¦r¨¦mie
%A Dan Cristian Vodnar
%A Daniela Hanganu
%A Ioana Matei
%A Sanda Andrei
%J Advances in Biological Chemistry
%P 209-227
%@ 2162-2191
%D 2023
%I Scientific Research Publishing
%R 10.4236/abc.2023.136015
%X This study has been conducted to analyze the chemical composition and antimicrobial, antioxidant and antiplasmodial properties of ethanol extracts of <em>Pycnostachys erici-rosenii</em> R.E.Fr and <em>Leucas martinicensis</em> (Jack.) R.Br that are not yet well known. The HPLC-DAD-MS-ESI<sup>+</sup> method was used to investigate the chemical profile, the disc diffusion and microdilution method for the antimicrobial activities, the DPPH and FRAP assays for antioxidant property and SYBR Green I-based growth inhibition assay on <em>Pf </em>3D7 (CQ-sensitive) strain for antiplasmodial properties. The results indicated significant amounts of hydroxybenzoic acid, flavonol and hydroxycinnamic acid in the two species. The total polyphenols analysis gave 209.0 ¡À 16.1 mg GAE/100g DW for <em>P. erici-rosenii</em> and 175.3 ¡À 1.6 mg GAE/100g DW for <em>L. martinicensis</em> while for total flavonoids analysis 33.4 ¡À 1.8 mg TE/100g DW was found for <em>P. erici-rosenii</em> and 39.6 ¡À 0.6 mg TE/100g DW for <em>L. martinicensis</em>. Moreover, antimicrobial tests revealed 0.125 mg/mL on <em>E. faecalis</em> ATCC25922 for ethanol extracts <em>P. erici-rosenii</em> and <em>L. martinicensis</em>. The antioxidant assays revealed IC<sub>50</sub> 56.17 ¦Ìg/mL and 78.43 ¦Ìg/mL for DPPH assay, and 112.03 ¦ÌM TE/100mL and 90.46 ¦ÌM TE/100mL) for FRAP assay for ethanol extracts of <em>P. erici-rosenii</em> and <em>L. martinicensis</em> respectively. Finally, for Antiplasmodial activity, IC<sub>50</sub> was 4.07 ¦Ìg/mL for <em>P. erici-rosenii</em> and 12.29 ¦Ìg/mL for <em>L. martinicensis</em>. Therefore, the antimicrobial, the antioxidant, and the antiplasmodial results suggest that the ethanolic extracts of the aerial parts of <em>P. erici-rosenii</em> and <em>L. martinicensis</em> contain compounds with antimicrobial, antioxidant, and antiplasmodial properties, which can be searched in new drug discovery for treatment of infectious diseases.
%K &lt
%K i&gt
%K Pycnostachys erici-rosenii&lt
%K /i&gt
%K &lt
%K i&gt
%K Leucas martinicensis&lt
%K /i&gt
%K Phytochemical Profile
%K Antimicrobial Activity
%K Antioxidant Activity
%K Antiplasmodial Activity
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=129598