%0 Journal Article
%T Lipoprotein (a) Cut-Off in Chronic Kidney Disease Patients with a History of Cardiovascular Disease in Center Hospital University Souro SANOU, Burkina Faso
%A Ollo Da
%A Aoua Semde
%A Arnaud Kouraogo
%A Emmanuel Zongo
%A Amidou Sawadogo
%A Aristide Zongo
%A Fatou Gueye Tall
%A Souleymane Fofana
%A Sanata Bamba
%A Georges Anicet Ouedraogo
%J Advances in Biological Chemistry
%P 228-235
%@ 2162-2191
%D 2023
%I Scientific Research Publishing
%R 10.4236/abc.2023.136016
%X Patients living with chronic kidney disease (CKD) are at high risk of cardiovascular events. Our aim in this study was to assess the cut-off value for lipoprotein (a) (Lp(a)) in CKD patients with a history of cardiovascular disease (CVD). This was a cross-sectional study. Variables including age, sex, history of CVD, body mass index and CKD stage, were collected during CKD patientĄ¯s first admission in the nephrology dialysis department. Blood samples were collected for quantitative determination of Lp(a) by immunoturbidimetric method. They were divided into two groups: CKD patients without history of CVD and CKD patients with history of CVD. FisherĄ¯s exact test was used to assess associations with a significance level of 0.05%. Area under the curve (AUC) and new cut-off value for Lp(a) were identified by drawing Receiver Operating Characteristic (ROC) curve. A total of seventy CKD patients with median age of 43 years [minimum-maximum = 15 - 78 years] were included. Patients with history of CVD were 65.71% (46/70). New Lp(a) cut-off point in CKD patients with history of CVD was 66.50 nmol/L [sensitivity, 87.00%; specificity, 58.30%; AUC = 0.727; p = 0.000]. ROC curve demonstrated good performance of Lp(a) to screen CKD patients with history of CVD. Further research is needed to determine an LPA gene polymorphismĄ¯s contribution to increasing risk for CVD at each kidney disease stage.
%K Lipoprotein (a)
%K Cut-Off
%K Chronic Kidney Disease
%K Cardiovascular Disease
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=129601