%0 Journal Article
%T Macrophage Activation Syndrome in a Context of Pre-B Type Lymphoblastic Acute Leucemia:  A Case Report
%A Mamadou Wagu¨¦ Gueye
%A Sokhna Moumi Mback¨¦ Daff¨¦
%A Mor Ngom
%A Maguette Ndoye
%A Papa Silman Diawara
%A Nata Dieng
%A Demba Makalou
%A Macoura Gadji
%A Macoura Gadji
%A Awa Oumar Tour¨¦/Fall
%A B¨¦caye Fall
%J Open Journal of Blood Diseases
%P 141-147
%@ 2164-3199
%D 2023
%I Scientific Research Publishing
%R 10.4236/ojbd.2023.134016
%X Macrophage
activation syndrome (MAS) is linked to inappropriate stimulation of macrophage
cells in the bone marrow and lymphoid system, resulting <span>in abnormal phagocytosis of figurative blood elements and the release of</span> pro-in<span>flammatory cytokines. It is a rare and
serious hyper-inflammat</span>ory condition of diagnostic and therapeutic
emergency. MAS is characterized by non-specific clinical and laboratory signs
associated with images of hemophagocytosis. MAS is either ¡°primary¡± (familial
or pediatric forms), or ¡°secondary/re<span>active¡±
to infection, neoplasia, or autoimmune disease. Hemop</span>athies dominate MAS
secondary to neoplasia. B-type acute lymphoblastic leukemia (ALL) is a
hematological malignancy characterized by the proliferation and accumulation of
B lymphoid progenitors, blocked at an early stage of differ<span>entiation, leading to suppression of polyclonal
hematopoiesis and subsequent development of signs associated with bone marrow
failure. In this context, we report the observation of a macroph</span>age
activation syndrome (MAS) associated with ALL, diagnosed at H&#244;pital Principal
de Dakar/Senegal, in a 69-year-old patient with a<span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:;\" \"=\"\">well-controlled type 2
diabetes under oral antidiabetic therapy (OAD) and good general condition.</span>
%K Macrophage Activation Syndrome
%K Acute Lymphoblastic Leukemia
%K Adult
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=129672