%0 Journal Article
%T Enhancing Accumulation and Penetration Efficiency of Next-Generation Antibiotics to Mitigate Antibiotic Resistance in <i>Pseudomonas aeruginosa</i> PAO1
%A Godspower Oghenemaroh Sebe
%A Supreme O. Oghenerhoro
%A Ogbole E. Jonathan
%A Ebuka Victor Anyaogu
%A Adeyemo David Adebowale
%A Raymond Chidozie Ntomchukwu
%J Journal of Biomedical Science and Engineering
%P 107-120
%@ 1937-688X
%D 2023
%I Scientific Research Publishing
%R 10.4236/jbise.2023.168008
%X <p>
	<br />
</p>
<p class=\"MsoNormal\">
	<span lang=\"EN-US\">This study explores the efficacy of
advanced antibiotic compounds against P. aeruginosa, focusing on Antibiotic B,
an enhanced derivative of Ceftriaxone. The study measured the intracellular
uptake of Antibiotic B and introduced a novel adjuvant, Influximax, which
augmented its antibacterial activity. Results showed a diminished potential for
resistance emergence with Antibiotic B, particularly when used in combination
with Influximax. The study suggests that optimizing antibiotic delivery into
bacterial cells and leveraging syner-gistic adjuvant combinations can enhance
drug resistance combat.<o:p></o:p></span> 
</p>
<p>
	<br />
</p>
%K Pseudomonas aeruginosa PAO1
%K Antibiotic Resistance
%K Next-Generation Antibiotics
%K Adjuvant  Synergy
%K Intracellular Accumulation
%K Penetration Rates
%K Minimum Inhibitory Concentration (MIC)
%K Resistance Tra-jectory
%K Fluorescence Quantification
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=129818