%0 Journal Article
%T Clinical and Bacteriological Profile of Infections in Sickle Cell Children in Two Referral Hospitals in Niamey, Niger
%A Kamaye Moumouni
%A Samaila Aboubacar
%A Garba Moumouni
%A Georges Thomas Ibrahim
%A Mamoudou Abdou Djafar
%A Mamane Halima
%A Hamadou Ibrahim
%A Hamani Issaka
%A Djibrilla Almoustapha Amadou
%A Yacouba Abdourahamane
%A Marou Soumana Boubacar
%A Moussa Saley Sahada
%A Bade Malam Abdou
%A Soumana Alido
%J Open Journal of Pediatrics
%P 36-42
%@ 2160-8776
%D 2024
%I Scientific Research Publishing
%R 10.4236/ojped.2024.141004
%X <strong>Introduction:</strong><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"> Infections are significant causes of mortality in
sickle cell ch</span></span></span><span><span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">ildren in resource-limited countries. This study
aimed to determine the clinical profile and bacterial ecology of infections in
children with sickle-cell disease in two referral hospitals in Niamey. </span><b><span style=\"font-family:Verdana;\">Patients
and methods: </span></b><span style=\"font-family:Verdana;\">A retrospective descriptive study was conducted from January
2018 to July 2020 in two referral hospitals in Niamey. All children aged one
(1) to 15 years with sickle cell dis</span><span style=\"font-family:Verdana;\">ease
admitted for suspected infection, including at least one bacterial cu</span><span style=\"font-family:Verdana;\">lture,
were studied. Bacteriological analysis was performed using the appropriate
culture media, using BactAlert (Reference 4700003 BTA3D60 BioM¨¦rieux). </span><b><span style=\"font-family:Verdana;\">Results: </span></b><span style=\"font-family:Verdana;\">Over 36-months, 350 children with a mean age of 10.9 months were admitted.
The sex ratio was 1.2. The SS electrophoretic profile was the most common
(93.4%). Immunization status was up to date in 66% of patients. Fever was the
common reason for consultation (55.1%). Infection was confirmed in 62 patients
(17.7%). The primary diagnoses were bacterial gastroenteritis (24.2%) and
urinary tract infection (19.4%). Blood cultures were isolated from </span><i><span style=\"font-family:Verdana;\">Salmonella typhi</span></i><span style=\"font-family:Verdana;\"> (13.0%) and </span><i><span style=\"font-family:Verdana;\">Escherichia coli</span></i><span style=\"font-family:Verdana;\"> (8.7%). </span><i><span style=\"font-family:Verdana;\">Klebsiella spp</span></i><span style=\"font-family:Verdana;\"> (7.1%) and </span><i><span style=\"font-family:Verdana;\">Escherichia coli</span></i><span style=\"font-family:Verdana;\"> (5.0%)</span></span></span></span><span><span><span style=\"font-family:&quot;\"> </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">were
detected </span></span></span><span><span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">in</span><span style=\"color:red;\"> </span></span></span></span><span><span><span style=\"font-family:&quot;\"><span
%K Sickle Cell Disease
%K Child
%K Infection
%K Niger
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=130387