%0 Journal Article
%T Association between the Different Phenotypes of Polycystic Ovary Syndrome and the Outcome in <i>in Vitro</i> Fertilization at Human Reproductive Center Paul et Chantal Biya-Yaoundé
%A Ngono Akam Vanina
%A Ngah Minala
%A Belinga Etienne
%A Belinga Etienne
%A Mpono Pascale
%A Nyada Serges
%A Onana Y. Kasia
%A Cho Joselyne
%A Kasia Florence
%A Adjessa Abega
%A Kasia Jean Marie
%J Open Journal of Obstetrics and Gynecology
%P 18-28
%@ 2160-8806
%D 2024
%I Scientific Research Publishing
%R 10.4236/ojog.2024.141003
%X <strong>Background:</strong><span style=\"font-family:&quot;\"> <i><span style=\"font-family:Verdana;\">In Vitro</span></i><span style=\"font-family:Verdana;\"> Fertilization/Intracytoplasmic Sperm Injection (IVF/ICSI) represents the final
step in the management of Polycystic Ovarian Syndrome (PCOS). Our objective was
to study the association between PCOS phenotypes and IVF/ICSI results in women
admitted to Gynaecological Endoscopic Surgery and Human Reproductive Teaching
Hospital (CHRACERH). </span><b><span style=\"font-family:Verdana;\">Material and Method:</span></b><span style=\"font-family:Verdana;\"> We carried out a cohort study
with historical-prospective data collection over a period of seven years
(January 2016 to March 2023) at Chracerh. PCO</span></span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">S patients were subdivided into 4 subgroups A, B, C and D. </span><b><span style=\"font-family:Verdana;\">Results:</span></b><span style=\"font-family:Verdana;\"> We recruited 128 patients including 64 PCOS patients divided into four
phenotypes and 64 non-PCOS patients constituting the control group. Phenotype D
without hyperandrogenism had used the lowest dose of gonadotropins, </span><i><span style=\"font-family:Verdana;\">i.e.</span></i><span style=\"font-family:Verdana;\"> 1939.7 ¡À 454.3 IU, and had produced
a greater quantity of estradiol on the day ovulation was triggered (6529.8 ¡À 4324.8
ng/ml). The average number of punctured follicles and mature oocytes were
higher in the phenotype D group. Ovarian hyperstimulation syndrome (OHSS)
occurred mainly in phenotype D (3/35), with an estimated prevalence of 2.3%.
The fertilization rate seemed lower in the hyperandrogenic phenotypes A, B, C
compared to the group without hyperan</span></span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">drogenism
without significant difference (p = 0.461). The biological pregnancy rate and
live birth rate were comparable between the different groups. </span><b><span style=\"font-family:Verdana;\">Conclusion: </span></b><span style=\"font-family:Verdana;\">Phenotype
D used less dose of gonadotropins. Biological pregnancy and live birth rates
were comparable between the different phenotypes.</span></span>
%K Phenotype
%K Polycystic Ovarian Syndrome
%K IVF/ICSI
%K Prognosis
%K CHRACERH
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=130437