%0 Journal Article
%T Post Thyroidectomy Assessment of Intact Parathyroid Hormone for Early Prediction of Hypocalcaemia
%A Md. Masum Billah
%A Ripon Kumar Sarkar
%A Md. Yousuf Ali
%A Saad Zaman
%A Md. Nazmul Hasan
%A Md. Shehab Uddin
%A Md. Mosleh Uddin
%A Kazi Shameemus Salam
%A Farzana Binte Abedin Leera
%J International Journal of Otolaryngology and Head & Neck Surgery
%P 71-84
%@ 2168-5460
%D 2024
%I Scientific Research Publishing
%R 10.4236/ijohns.2024.132008
%X <strong>Backg</strong><span><strong>rou</strong><strong>nd:</strong></span><span style=\"font-size:10.0pt;font-family:;\" \"=\"\"> As the half-life of intact parathyroid hormone (iPTH) is v</span><span style=\"font-size:10.0pt;font-family:;\" \"=\"\">ery low, it reflects
parathyroid insufficiency within minutes to hours after total thyroidectomy.
Therefore, iPTH level assessment in the postoperative period can be used to
predict the development of hypocalcaemia. The optimal time point to measure
serum iPTH is important for the accurate prediction of hypocalcaemia. <b>Aim:</b> </span><span style=\"font-size:10.0pt;font-family:;\" \"=\"\">This paper aims </span><span style=\"font-size:10.0pt;font-family:;\" \"=\"\">to evaluate the ability of iPTH as an early predictive marker of
hypocalcaemia and determine which time iPTH is more <span>able to predict postoperative hypocalcaemia. <b>Method:</b> This prospect</span>ive
observational study<b> </b>was conducted in the Department of
Otolaryngology-Head &amp; Neck Surgery, BSMMU, Dhaka, from July 2020 to
December 2021, with 67 patients who underwent total thyroidectomy. iPTH levels
were measured on the day before the operation and at 1 hour, 4 hours, and 24
hours after the operati<span>on. S.calcium levels
were measured on the day before the ope</span>ration and 1<sup>st</sup> postoperative day. All the data were compiled and sorted properly and were
analyzed statistically. <b>Results:</b> Postoperative hypocalcaemia developed
in 18 cases, with an incidence of 26.9%. Pearson correlation showed a
significant correlation between postoperative iPTH at 1 hr, 4 h, and 24 hr with
1st postop<span>er</span><span>ative calcium value. The Receiver operating characteristic (RO</span><span>C) curve was processed for the postoperative iPTH
at 1 hr, 4 h, and 24 hr. The sensitivity, specificity, cut-off value, and mean
AUC found 93.9%, 94.4</span>%, ¡Ü14.0, 0.988; 95.9%, 94.4%, ¡Ü09.5, 0.993 and
91.8%, 94.4%, ¡Ü11.0, 0.993 respectively. <b>Conclusion:</b> iPTH can be used as
an early predictor of post-thy</span><span style=\"font-size:10.0pt;font-family:;\" \"=\"\">-</span><span style=\"font-size:10.0pt;font-family:;\" \"=\"\">roidectomy hypocalcaemia. 4 hr iPTH showed more
sensitivity and specificity for a cut-off value near the laboratory reference
range.</span>
%K Total Thyroidectomy
%K Hypocalcaemia
%K Serum Intact Parathyroid Hormone
%K Early Predictor of Hypocalcaemia
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=131307