%0 Journal Article
%T 优思明联合二甲双胍治疗多囊卵巢综合征的疗效Meta分析
Meta-Analysis of the Efficacy of Yasmin Combined with Metformin in the Treatment of Polycystic Ovary Syndrome
%A 何芝挺
%A 杨莉梅
%A 刘学庆
%J Hans Journal of Medicinal Chemistry
%P 33-50
%@ 2331-8295
%D 2024
%I Hans Publishing
%R 10.12677/HJMCe.2024.121006
%X 目的：系统评价优思明联合二甲双胍治疗多囊卵巢综合征(Polycystic ovary syndrome, PCOS)的疗效和安全性。方法：检索中国知网、万方、维普、CBM、PubMed、the Cochrane Library、EMBASE数据库，检索时间为建库至2023年12月8日。共纳入31篇研究，研究对象共2792例，其中观察组1396例，对照组1396例。结果：Meta分析结果表明，观察组与对照组相比，在提高临床总体有效率(RR = 1.25, 95%CI [1.18, 1.33], P < 0.00001)、排卵率(RR = 1.63, 95%CI [1.62, 2.02], P < 0.00001)、妊娠率(RR = 2.03, 95%CI [1.44, 2.86], P < 0.0001)方面和改善体重指数BMI (MD = ？1.80, 95%CI [？2.34, ？1.26], P < 0.0002)、黄体生成素LH (MD = ？3.08, 95%CI [？3.82, ？2.34], P < 0.00001)、睾酮T (MD = ？0.44, 95%CI [？0.65, ？0.24], P < 0.0001)、空腹胰岛素FINS (MD = ？5.4, 95%CI [？1.26, ？0.30], P < 0.05)、空腹血糖 FBG (MD = ？1.54, 95%CI [？2.36, ？0.38], P < 0.05)、胰岛素抵抗指数HOMA-IR (MD = ？1.07, 95%CI [？1.31, ？0.84], P < 0.05)、不良反应发生率(RR = 0.61, 95%CI [0.41, 0.92], P < 0.05)方面差异有统计学意义；在雌二醇E2 (MD = 0.19, 95%CI [？17.36, 1.84], P > 0.05)和促卵泡生成素FSH (MD = ？0.40, 95%CI [？0.92, 0.13], P > 0.05)的没有统计学意义上的差异。结论：联合使用优思明和二甲双胍可以改善多囊卵巢综合征患者体内的激素紊乱水平、提高的妊娠能力、缓解体脂过高。
Objective: To evaluate the efficacy and safety of Yasmin combined with metformin in the treatment of Polycystic ovary syndrome (PCOS). Methods: the databases of CNKI, Wanfang, VIP, CBM, PubMed, the Cochrane Library and EMBASE were searched from December 8, 2023. A total of 31 studies were included, with a total of 2792 subjects, including 1396 in the observation group and 1396 in the control group. Results: meta-analysis showed that compared with the control group, the clinical overall response rate (RR = 1.25, 95%CI [1.18, 1.33], P < 0.00001) and ovulation rate (RR = 1.63, 95%CI [1.62, 2.02] were improved in the observation group. P < 0.00001), Pregnancy rate (RR = 2.03, 95%CI [1.44, 2.86], P < 0.0001) and improved body mass index (MD = ？1.80, 95%CI [？2.34, ？1.26], P < 0.0002), luteinizing hormone LH (MD = ？3.08, 95%CI [？3.82, ？2.34], P < 0.00001), tes-tosterone T (MD = ？0.44, 95%CI [？0.65, ？0.24], P < 0.0001), fasting insulin FINS (MD = ？5.4, 95%CI [？1.26, ？0.30], P < 0.05), fasting blood glucose FBG (MD = ？1.54, 95%CI [？2.36, ？0.38], P < 0.05), insulin resistance index HOMA-IR (MD = ？1.07, 95%CI [？1.31, ？0.84], P < 0.05), the incidence of adverse reactions (RR = 0.61, 95%CI [0.41, 0.92], P < 0.05) were statistically significant. There were no statistically significant differences between estradiol E2 (MD = 0.19, 95%CI [？17.36, 1.84], P > 0.05) and follicle-stimulating hormone FSH (MD = ？0.40, 95%CI [？0.92, 0.13], P > 0.05). Conclusion: Combined use of Yasmin and metformin can improve hormone disturbance levels, increase pregnancy capacity, and reduce high body fat in
%K 多囊卵巢综合征，优思明，二甲双胍，Meta分析
Polycystic Ovary Syndrome
%K Yasmin
%K Metformin
%K Meta-Analysis
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=81158