%0 Journal Article
%T Serum Immunoglobulin Concentrations in Juvenile Idiopathic Arthritis Cases during Active and Inactive Disease States
%A Sajib Muhammad Rayhan
%A Kamrul Laila
%A Shahana A. Rahman
%J Open Journal of Rheumatology and Autoimmune Diseases
%P 49-59
%@ 2164-005X
%D 2024
%I Scientific Research Publishing
%R 10.4236/ojra.2024.142006
%X <b><span style=\"font-family:Verdana;\">Background: </span></b><span style=\"font-family:Verdana;\">Juvenile idiopathic arthritis (JIA) is the most
common rheumatic disease in</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">children.
Both the humoral and cell mediated immunities are involved in</span><span style=\"font-family:Verdana;\"> the</span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\"> pathogenesis of JIA. It is
reported that overall immunoglobulin levels in JIA patients are significantly
higher than their control during the active state of disease. </span><b><span style=\"font-family:Verdana;\">Methodology: </span></b><span style=\"font-family:Verdana;\">This
prospective observational study was conducted over a period of 18 months All
the newly diagnosed oligo-articular and poly-articular JIA patients having
active disease were included by purposive sampling. Data were collected by a
semi-structured predesigned questionnaire. </span><b><span style=\"font-family:Verdana;\">Result: </span></b><span style=\"font-family:Verdana;\">Most of the study
subjects (57.6%) belonged to age group &gt;</span></span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">3 - 9 years. Oligo JIA was diagnosed in 66.7% and
poly JIA in 33.3%</span><span> </span><span style=\"font-family:Verdana;\">of JIA
children. The difference in</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">mean
(”ĄSD) ESR (33.52</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">”Ą</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">21.29 and 15.09</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">”Ą</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">7.71 mm in 1st hour) at active and inactive states</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">was highly significant. Mean
(”ĄSD) difference of IgG, IgM and IgA in active and inactive states</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">of disease were highly
significant. </span><b><span style=\"font-family:Verdana;\">Conclusion: </span></b><span style=\"font-family:Verdana;\">Higher and abnormal levels of immunoglobulin
(IgG, IgM, and IgA) were present among JIA patients</span></span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:Verdana;\">in active
%K JIA
%K Oligoarticular JIA
%K Polyarticular JIA
%K Immunoglobulins
%K Acitive Disease
%K Inactive Disease
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=132068