%0 Journal Article
%T Respiratory Mechanics, Respiratory Muscle Strength, Control of Ventilation and Gas Exchange in Patients with Autoimmune Liver Disease
%A Ahmet Baydur
%A Jacob Korula
%J Open Journal of Respiratory Diseases
%P 25-38
%@ 2163-9418
%D 2024
%I Scientific Research Publishing
%R 10.4236/ojrd.2024.142003
%X Objectives: To assess respiratory elastance and resistive
properties in patients with autoimmune liver disorders using the passive
relaxation expiration technique and compare findings to a group of patients
with non-autoimmune liver disease and control subjects. These findings were
then related to control of ventilation and gas exchange. A secondary objective
was to assess respiratory muscle strength and gas exchange and their relation
to respiratory mechanics. Methods: Measurements included respiratory
elastance and resistance using the passive relaxation method. Pulmonary
function, gas exchange and control of ventilation were assessed using standard
methods. Results: a) Compared to control subjects, Ers in patients with
liver disease was on average 50% greater than in controls; b) mean respiratory
resistance, expressed as the respiratory constants, K1 and K2 in the Rohrer relationship, Pao/V¡¯ = K1 + K2V¡¯, was not
different from control resistance; c) mean maximal inspiratory and maximal
expiratory pressures averaged 36% and 55% of their respective control values;
d) inspiratory occlusion pressure in 0.1 sec (P0.1) was increased
and negatively associated with FVC; and e) increases in P0.1, mean
inspiratory flow (Vt/Ti) and presence of respiratory alkalosis confirmed the
increase in ventilatory drive. Despite inspiratory muscle weakness in patients,
P0.1/Pimax averaged 5-fold higher than in control subjects. Conclusions:
%K Autoimmune Liver Disease
%K Control of Ventilation
%K Occlusion Pressure
%K Passive Relaxation Method
%K Primary Biliary Cirrhosis
%K Respiratory Elastance
%K Respiratory Resistance
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=132097