%0 Journal Article
%T PSMD2在肿瘤中的研究进展<br>Research Progress of PSMD2 in Cancer
%A 余远离
%A 刘伟利
%A 钱延玲
%J Medical Diagnosis
%P 142-148
%@ 2164-5418
%D 2024
%I Hans Publishing
%R 10.12677/md.2024.141021
%X 泛素蛋白酶体途径(Alterations in the ubiquitin-proteasome system UPS)，是由泛素介导的一种高度复杂的蛋白降解系统，普遍参与各种生物学功能，例如细胞生长，细胞周期进程，DNA转录、损伤、修复和信号转导及自噬，因此在体内各种调节蛋白的降解和整体细胞的稳态中发挥着至关重要的作用。UPS的表达功能异常或改变可能导致蛋白质的积累，与人类多种疾病相关，包括恶性肿瘤、血液系统疾病等。其中泛素化是泛素蛋白酶体系统途径的关键步骤，PSMD2 (proteasome 26S subunit, non-ATPase 14)位于蛋白酶体26S亚基，是一种非ATP酶组分，是泛素–蛋白酶体的重要组成部分之一。近年来，其在疾病发生发展中的作用越来越受到关注，本文将对PSMD2的结构、作用机制及在不同疾病中的研究进展进行综述。<br />
Alterations in the ubiquitin-proteasome system UPS, a highly complex protein degradation system mediated by ubiquitin, are commonly involved in a variety of biological functions, such as cell growth, cell cycle processes, DNA transcription, damage, repair and signal transduction, as well as autophagy, therefore play a crucial role in the degradation of various regulatory proteins in the body and overall cell homeostasis. Abnormal or altered expression function of UPS may lead to accumulation of proteins, which is associated with a variety of human diseases, including malignant tumors and diseases of the blood system. Ubiquitination is a key step in the pathway of the ubiquitin-proteasome system. PSMD2 (proteasome 26S subunit, non-ATPase 14), which is located in the 26S subunit of the proteasome, is a non-ATPase component and one of the important components of ubiquitin-proteasome. In recent years, the role of PSMD2 in the occurrence and development of diseases has attracted more and more attention. In this article, the structure, mechanism of action and research progress of PSMD2 in different diseases will be reviewed.
%K 泛素–蛋白酶体，PSMD2肿瘤<br>Ubiquitin Proteasome
%K PSMD2 Tumor
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=83447