%0 Journal Article
%T ω-3多不饱和脂肪酸改善2型糖尿病研究进展<br> Research Progress of ω-3 Polyunsaturated Fatty Acids in Improving Type 2 Diabetes
%A 周梦柔
%A 兰咏梅
%A 阿赛古丽
%J Bioprocess
%P 34-42
%@ 2164-5582
%D 2024
%I Hans Publishing
%R 10.12677/BP.2024.141005
%X 2型糖尿病(type 2 diabetes mellitus, T2DM)是遗传与环境共同作用的结果，目前公认的2型糖尿病的病理生理变化主要涉及到胰岛素抵抗和胰岛β细胞功能受损。许多研究显示，在T2DM发生发展过程中，炎症与氧化应激是调控胰岛素分泌的重要发病因素。ω-3多不饱和脂肪酸(ω-3 polyunsaturated fatty acid, ω-3PUFAs)在调节炎症反应、糖脂代谢、氧化与抗氧化反应等方面具有重要作用。但能否有效改善T2DM的发病风险，目前尚存争议。本文结合近年来国内外的相关研究进展，综述了ω-3PUFAs在T2DM发病风险的具体作用机制。探讨饮食营养对改善T2DM的意义，为ω-3PUFAs改善T2DM以及相关营养干预提供依据。<br />
Type 2 diabetes (T2DM) is the result of the interaction of heredity and environment. At present, the pathophysiological changes of type 2 diabetes are mainly related to insulin resistance and pancreatic β Impaired cellular function. Many studies have shown that inflammation and oxidative stress are important pathogenic factors regulating insulin secretion during the occurrence and development of T2DM. ω-3 polyunsaturated fatty acids (ω-3 PUFAs) play important roles in regulating inflammatory responses, glucose and lipid metabolism, oxidation, and antioxidant responses. However, there is still controversy over whether it can effectively im-prove the risk of developing T2DM. This article reviews the relevant research progress both domestically and internationally in recent years ω-The specific mechanism of action of ω-3 PUFAs in the risk of developing T2DM. Exploring the significance of dietary nutrition in improving T2DM, in order to ω-3 PUFAs provide a basis for improving T2DM and related nutritional interventions.
%K 2型糖尿病，ω-3多不饱和脂肪酸，炎症，氧化应激，胰岛素抵抗，胰岛β细胞<br> Type 2 Diabetes
%K ω-3 Polyunsaturated Fatty Acids
%K Inflammation
%K Oxidative Stress
%K Insulin 
Resistance
%K Pancreatic β-Cells
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=83439