%0 Journal Article
%T 不对称C-N交叉偶联反应的研究进展<br>Research Progress of Asymmetric C-N Cross-Coupling Reaction
%A 王灵强
%A 王亮霞
%J Journal of Organic Chemistry Research
%P 31-47
%@ 2330-524X
%D 2024
%I Hans Publishing
%R 10.12677/jocr.2024.121003
%X 在过去几十年中，C-N交叉偶联反应构建手性胺类化合物在药物、材料和催化领域发挥了着重要作用。然而，由于C-N键具有更高的键解离能，利用不对称C-N交叉偶联方法在构建中心手性、平面手性、轴手性和螺环手性化合物存在一些局限性。本文重点介绍了目前成熟的构建不对称C-N键的方法，如过渡金属Pd与Cu催化、手性有机小分子催化，并简要概括其化学实用性。<br />
In the past few decades, the construction of chiral amines by C-N cross-coupling reactions has played an important role in the fields of drugs, materials and catalysis. However, due to the higher bond dissociation energy of the C-N bond, the asymmetric C-N cross-coupling method has some limitations in the construction of central chiral, planar chiral, axial chiral and spirocyclic chiral compounds. This review focuses on the current mature methods for the construction of asymmetric C-N bonds, such as transition metal Pd and Cu catalysis, chiral organic small molecule catalysis, and briefly summarizes their chemical practicability.
%K C-N偶联，胺化反应，过渡金属，有机小分子<br>C-N Coupling
%K Amination Reaction
%K Transition Metals
%K Small Organic Molecules
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=83296