%0 Journal Article
%T Coumestan类天然产物合成及其生物活性研究进展<br>Research Progress on the Synthesis and Biological Activity of Coumestan Natural Products
%A 马钰栋
%A 张丽琼
%J Journal of Organic Chemistry Research
%P 96-110
%@ 2330-524X
%D 2024
%I Hans Publishing
%R 10.12677/jocr.2024.121008
%X Coumestans是一类以四环内酯为核心骨架的天然产物，主要存在于蝶形花科(<i>Papilionaceae</i>)，豆科(<i>Leguminosae</i>)，菊科(<i>Compositae</i>)等植物中，具有广泛的药理作用和生理活性，如抗肿瘤、抗菌、抗病毒、止血、治疗骨质疏松、雌激素样作用等。近年来，随着化学合成和生物技术的发展，人们对Coumestan类天然产物的骨架构筑及其生物活性进行了深入研究。本文将全面梳理Coumestan类天然产物的结构特征、骨架构筑方法以及其生物活性方面的最新研究进展。<br />
Coumestans are a class of natural compounds characterized by a four-ring lactone as their core structure. They are predominantly found in plants of the Fabaceae (<i>Papilionaceae</i>), <i>Leguminosae</i>, <i>Compositae</i>, and other botanical families, exhibiting diverse pharmacological and physiological activities such as anti-tumor, antimicrobial, antiviral, hemostatic, treatment of osteoporosis, and estrogenic effects. In recent years, with advancements in chemical synthesis and biotechnology, there has been a profound exploration of the scaffold construction and biological activities of coumestan-type natural products. This article aims to comprehensively review the structural features, methods of scaffold construction, and the latest research developments in the biological activities of coumestan-type natural products.
%K Coumestan类天然产物，香豆素，四环内酯，骨架构筑，生物活性<br>Coumestan Natural Products
%K Coumarin
%K Tetracyclic Lactone
%K Skeleton Construction
%K Biological Activity
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=83612