%0 Journal Article
%T 吡咯里西啶生物碱的合成研究进展<br>Research Progress in the Synthesis of Pyroriliidine Alkaloids
%A 李治乔
%A 丹智才让
%A 张怡
%J Journal of Organic Chemistry Research
%P 149-162
%@ 2330-524X
%D 2024
%I Hans Publishing
%R 10.12677/jocr.2024.122012
%X 吡咯里西啶生物碱是天然产物中常见的结构成分之一，具有广泛的生物和药理活性。鉴于其强大的生物活性和相对较低的丰度，吸引了许多合成化学家的关注。这些化学家对这些偶氮双环系统表现出浓厚兴趣，因此提出了多种不同的合成策略用于制备各种吡咯里西啶衍生物，并研究其作为抗菌、抗病毒、抗肿瘤、抗糖尿病、免疫刺激剂或抗炎药物的潜在用途。在本文中主要综述了几类具有生物活性的吡咯里西啶生物碱的合成路径，重点介绍了其结构和主要合成方法，以为这一研究领域的进一步发展铺平道路。<br />
Pyroriliidine alkaloids are one of the common structural components in natural products with a wide range of biological and pharmacological activities. Currently, due to their strong biological activity and relatively low abundance, these compounds have attracted the attention of many synthetic chemists. These chemists showed great interest in these azo bicyclic systems, proposed a variety of different synthesis strategies to prepare various pyrrolizidine derivatives, and studied their potential uses as antibacterial, antiviral, anti-tumor, anti diabetes, immunostimulatory or anti-inflammatory drugs. In this article, we primarily examined the synthesis routes of a number of bioactive pyrrolizidine alkaloids, emphasizing their primary synthesis techniques and structures, hence opening the door for future advancements in this area of study.
%K 吡咯里西啶生物碱，偶氮双环，生物活性，药理活性<br>Pyroriliidine Alkaloids
%K Azo Bicyclic Systems
%K Biological Activities
%K Pharmacological Activities
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=83788