%0 Journal Article %T Simulation and Experimental Study of Staple Line Reinforcement Surgery %A Chengjie Hu %A Jian Zhang %J Journal of Biomedical Science and Engineering %P 83-95 %@ 1937-688X %D 2024 %I Scientific Research Publishing %R 10.4236/jbise.2024.174007 %X The aim of this study was to evaluate the effectiveness of BM (basement membrane) and SIS (small intestine submucosa) composite extracellular matrix staple line reinforcement in surgical procedures through finite element modelling simulations and leak-proof performance experiments. The mechanical analyses of soft tissues with and without staple line reinforcement were performed by establishing finite element models of three tissues, namely, stomach, intestine and lungs, under the use scenarios of different anastomosis staple models; and the leak-proof performance of the staple line reinforcement was evaluated by simulating leak-proof experiments of gastric incision margins, intestinal sections, and lung incision margins <i>in vitro</i>. The results showed that the equivalent average stresses of the staple line reinforcement were increased by 20 kPa-68 kPa in gastric and intestinal tissues, and 8 kPa-22 kPa in lung tissues. and that the BM and SIS composite extracellular matrix staple line reinforcement could strengthen the anastomotic structure, and at the same time disperse the high stresses of the anastomosed tissues, which could effectively reduce the postoperative complications such as anastomotic bleeding and anastomotic leakage, and provide a safer and more effective optimized design for surgical mechanical anastomosis. It can effectively reduce postoperative complications such as anastomotic bleeding and anastomotic leakage, and provide a safer and more effective optimized design for surgical mechanical anastomosis. %K Staple Line Reinforcement %K Surgical Anastomosis %K Soft Tissue Damage %K Finite Element Analysis %K Leak-Proof Performance ExperimentsStaple cartridge %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=132290