%0 Journal Article
%T Synthesis and Physico-Chemical Characterizations of Novel Hydrazone Ligands and Their Metal Complexes against Hormone-Dependent and Independent Cancers
%A Sommai Patitungkho
%A Kingkaew Patitungkho
%J Open Journal of Medicinal Chemistry
%P 1-13
%@ 2164-313X
%D 2024
%I Scientific Research Publishing
%R 10.4236/ojmc.2024.141001
%X This work deals with the synthesis and physicochemical characterizations of a new group of novel retinoidal ligands and their metal complexes. Their <i>in v</i><i>i</i><i>tro</i> anti-proliferative activities have shown that ligand <b>L1</b> is effective against human breast cancer BT-20 and MCF-7 cell lines. At the same time, compound <b>L2</b> exerts its effect on human prostate cancer PC-3 and human breast cancer MDA-MB-231 and MCF-7 cell lines respectively. The retinoid ligands exert their pleiotropic action toward retinoic acid receptors (RARs) than their metal complexes but all compounds exhibit concentration-dependent.
%K Metal Complexes
%K Cancers
%K Antioxidant
%K Hydrazone
%K Retinoid Receptors
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=132374