%0 Journal Article
%T 肠道微生物在急性砷暴露导致的肠道屏障损伤中的治疗研究进展<br>Research Progress on the Treatment of Gut Microbes in Intestinal Barrier Damage Caused by Acute Arsenic Exposure
%A 李庚
%J Bioprocess
%P 64-74
%@ 2164-5582
%D 2024
%I Hans Publishing
%R 10.12677/bp.2024.142009
%X 众所周知，砷是一种有毒的类金属。砷的污染尤其是砷水污染在今天依然存在，全球有2亿人暴露于含砷的饮用水中，进而导致一系列身体损害。砷暴露导致的砷吸收主要来自小肠，稳定的肠道屏障有一定的自我防御机制，可以抵抗砷暴露带来的损害。肠道微生物在维护肠道屏障中发挥着至关重要的作用。例如，补充某些益生菌，或含有特定砷代谢功能的肠道微生物可以加速砷的代谢和螯合。更重要的是，某些肠道微生物可以增加肠道屏障，保护肠道屏障，进而缓解砷对肠道屏障造成的损伤。因此本研究通过查阅国内外文献，综述了肠道微生物及肠道微生物在砷暴露中的作用研究，为今后深入探讨其他未发现的肠道微生物在砷暴露中的作用提供研究方向。<br />
Arsenic is a toxic, metal-like substance. Arsenic pollution, especially arsenic water pollution, still exists today, and 200 million people worldwide are exposed to arsenic-containing drinking water, leading to a range of physical damage. The absorption of arsenic caused by arsenic exposure mainly originates from the small intestine, and the stable intestinal barrier has a self-defense mechanism to resist the damage caused by arsenic exposure. Gut microbes play a vital role in maintaining the gut barrier. For example, supplementation with certain probiotics or gut microbes with specific arsenic metabolic functions can accelerate arsenic metabolism and chelation. More importantly, certain gut microbes can increase and protect the gut barrier, which in turn can alleviate the damage caused by arsenic to the intestinal barrier. Therefore, by referring to domestic and foreign literature, this study reviewed gut microbes and their role of gut microbes in arsenic exposure, providing a research direction for further exploration of the role of other undiscovered gut microbes in arsenic exposure.
%K 肠道微生物，急性砷暴露，肠道屏障，改善<br>Gut Microbes
%K Acute Arsenic Exposure
%K Intestinal Barrier
%K Improvement
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=87493