%0 Journal Article
%T One-Pot Green Synthesis of 1, 4-Dihydropyridine Derivatives Using Polyindole TiO<sub>2</sub> Nanocatalyst by Solvent Free Method
%A Deepak Babasaheb Phasage
%A Sanjay K. Sharma
%A Balram Tripathi
%A Sonia Chahar Srivastava
%J Open Journal of Composite Materials
%P 109-123
%@ 2164-5655
%D 2024
%I Scientific Research Publishing
%R 10.4236/ojcm.2024.143008
%X This study used a Polyindole in combination with TiO<sub>2</sub> nanocatalyst as an efficient heterogeneous catalyst to carry out a multi-component Hantzsch reaction involving different aromatic aldehydes with methyl acetoacetate, and aqueous ammonium to create 1,4-dihydropyridine derivatives under solvent free condition at ambient temperature. A broad range of aldehydes and methyl acetoacetates, ranging from heteroaromatic to polyaromatic one, with high level of functional group tolerance can be used to provide the desired products possessing relevant medicinal moiety in high yields. This technology has prospective advantages over current protocols, including the utilization of a cheap, stable, recyclable, and safe catalyst, quicker reaction times with higher yields and simple product isolation.
%K TiO<sub>2</sub>
%K Nanocatalyst
%K Green Synthesis
%K Surface Morphology
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=133816