%0 Journal Article %T β,γ-不饱和-α-酮酸酯在有机合成中的应用研究进展
Research Progress in the Organic Synthesis of β,γ-Unsaturated-α-Ketoesters %A 孔祥南 %A 郑玥 %A 张虎虎 %J Journal of Organic Chemistry Research %P 306-317 %@ 2330-524X %D 2024 %I Hans Publishing %R 10.12677/jocr.2024.122028 %X β,γ-不饱和-α-酮酸酯是一类具有特殊共轭结构的有机中间体，其在有机合成中可以充当C1、C2、C3和C4合成子，可以用于合成具有手性结构或者非手性结构的化合物，因此，β,γ-不饱和-α-酮酸酯已成为现代有机合成中极具吸引力且用途广泛的合成子。本文重点介绍了β,γ-不饱和-α-酮酸酯作为不同合成子在有机合成中的应用，如不对称1,4-加成反应、[2 + 3]环加成反应、[3 + 2]环加成反应以及构建螺环化合物和六元杂环化合物的应用。
β,γ-Unsaturated-α-ketoesters are a class of organic intermediates with a unique conjugated structure, which can serve as C1, C2, C3, and C4 synthons in organic synthesis, and can be used to synthesize compounds with chiral or non-chiral structures. Therefore, β,γ-unsaturated-α-ketoesters have become highly attractive and versatile building blocks in modern organic chemistry. This review focuses on introducing β,γ-Unsaturation-α- the application of ketone esters as different synthons in organic synthesis, such as asymmetric 1,4-addition reactions, [2 + 3] cycloaddition reactions, [3 + 2] cycloaddition reactions, as well as the construction of spirocyclic compounds and hexagonal heterocyclic compounds. %K β %K γ-不饱和-α-酮酸酯，合成子，有机中间体
β %K γ-Unsaturated-α-Ketoesters %K Building Blocks %K Organic Intermediates %U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=89868