%0 Journal Article
%T 二氢吡咯里嗪化合物的合成研究进展<br>Research Progress in the Synthesis of DihydropyrrolizineCompounds
%A 孔祥南
%A 刘飞宇
%A 张虎虎
%J Journal of Organic Chemistry Research
%P 406-420
%@ 2330-524X
%D 2024
%I Hans Publishing
%R 10.12677/jocr.2024.122039
%X 二氢吡咯里嗪骨架是由两个稠合的吡咯环组成的双环体系，广泛存在于许多天然产物、药物分子以及人工合成的化合物中，因此，发展高效合成二氢吡咯里嗪骨架的方法具有良好的研究价值和应用前景。目前以吡咯或四氢吡咯衍生物为原料合成二氢吡咯里嗪衍生物的方法主要有两种：一种是通过分子内环化反应来构建二氢吡咯里嗪骨架；另一种是通过分子间环加成反应来合成此类化合物。本文中主要介绍了一些二氢吡咯里嗪化合物的应用以及二氢吡咯里嗪化合物的合成方法，为这一类化合物的合成研究提供一定基础。<br />
The dihydropyrrolizine framework is a bicyclic system composed of two fused pyrrole rings, widely present in many natural products, drug molecules, and compounds synthesized artificially. Therefore, the development of efficient methods for synthesizing dihydropyrrolizine moiety holds significant research value and application prospects. Currently, there are two main methods for synthesizing dihydropyrrolizine compounds from pyrrole or tetrahydropyrrole derivatives: one is to construct this framework through intramolecular cyclization reactions, while another approach is to synthesize such compounds through intermolecular cycloaddition reactions. This review mainly introduces the applications of some dihydropyrazine compounds and the synthesis methods of dihydropyrazine compounds, providing a certain foundation for the synthesis research of this type of compound.
%K 二氢吡咯里嗪衍生物，分子内环化反应，分子间环加成反应<br>Dihydropyrrolizine Compounds
%K Intermolecular Cyclization Reactions
%K Intermolecular Cycloaddition Reactions
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=90928