%0 Journal Article
%T Pediatric Nephrotic Syndrome in a Cameroonian Cohorte: The Beast to Slaughter
%A Maimouna Mahamat
%A Kalla Claude
%A Diya Rahinatou
%A Epee Ngoue Jeannette
%A Gamarko Sossal Ousmane
%A Kaze Folefack Fran&#231
%A ois
%A Koki Ndombo Paul Olivier
%J Open Journal of Nephrology
%P 386-396
%@ 2164-2869
%D 2024
%I Scientific Research Publishing
%R 10.4236/ojneph.2024.143036
%X <b>Background:</b> Idiopathic nephrotic syndrome (INS) is a frequent pathology in children. There is little data on the future of NS in children in sub-Saharan Africa, particularly Cameroon. The aim of our study is to report the prognosis of children treated for nephrotic syndrome in the city of Yaound&#233;. <b>Method</b><b>: </b>This was an analytical cross-sectional study with retrospective collection in 4 reference hospitals in the Cameroonian capital over a period of five years from January 1, 2018 to December 31, 2022. We included all medical records of patients treated for idiopathic INS. We excluded incomplete records and those with a history of chronic kidney disease. The sociodemographic, clinical, paraclinical, and therapeutic data, as well as the short-term evolution were collected in the files. Data was analysed using the software statistical package for social sciences version 25.0. Statistical significance was set at a p-value &lt;0.05. <b>Results: </b>A total of 131 children (58% boys) were included in our study over a period of 5 years. The median age was 8 [6 - 11] years. Median proteinuria was 5 g/24h [3 - 8.4], median serum protein was 39 [34 - 46] g/l and median estimated glomerular filtration rate was 130.36 [68 - 174.6] ml/min/1.73m<sup>2</sup>. During steroid therapy, 45.07% were in partial remission at 2 months, 16.9% were in complete remission at 4 and 6 months, and 37.25% had relapsed. Steroid sensitivity was reported in 28.17% of cases, steroid resistance in 64.78% of cases and steroid dependent in 7.04% of cases. The mortality rate was 12.97%. Survival time averaged 48.2 months, with an overall crude survival rate of 99.2% at 3 and 6 months and 98.4% at 1 year. Regarding renal survival, renal function was impaired in 8.33% of patients at 6 months and 9% at 12 months. <b>Conclusion: </b>Idiopathic nephrotic syndrome is a common disease in children. Its evolution depends on corticosteroid therapy. The long-term prognosis is dominated by the risk of progression to end-stage kidney disease or even death. Rigorous and affordable follow-up is essential to reduce the number of patients lost to follow-up and the occurrence of complications.
%K Idiopathic Nephrotic Syndrome
%K Outcome
%K Mortality
%K End-Stage Kidney Disease
%K Children
%K Cameroon
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=136468