%0 Journal Article
%T Virus-Encoded MicroRNAs Reveal How Ranavirus Interacts with Amphibian Immune Defense
%A Aaron Yang
%J Journal of Biomedical Science and Engineering
%P 179-184
%@ 1937-688X
%D 2024
%I Scientific Research Publishing
%R 10.4236/jbise.2024.1710014
%X Ranaviruses are harmful viruses that infect amphibians, fish, and reptiles, and have caused particularly devastating declines in amphibian populations. One particular type of ranavirus, called Frog Virus 3 (FV3), has been extensively studied due to its prevalence and impact on amphibians. Previous research has primarily focused on the virus’s genes, but little attention has been given to the non-coding regions of its genome. This article reviews recent studies that reveal the ability of ranaviruses, including FV3, to encode microRNA (miRNA), a type of regulatory RNA. These viral miRNAs play a crucial role in suppressing frog immune genes, modulating the virus-host interaction, and promoting viral infection. Understanding how ranaviruses use miRNAs to control disease progression is essential for addressing the health threat they pose to wildlife and ecosystems.
%K Ranaviruses
%K Amphibians
%K Virus-Encoded MicroRNA
%K Frog Virus 3
%K Virus-Host Interaction
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=136739