%0 Journal Article
%T Trombocitopenia severa neonatal
%A Moreira
%A Am¨¦lia
%A Vale
%A Maria Jos¨¦
%A Neves
%A Joana
%A Dias
%A Clara Paz
%J Nascer e Crescer - Revista do Hospital de Crian£¿as Maria Pia
%D 2011
%I Scientific Electronic Library Online
%X introduction: thrombocytopenia in the first hours of life is generally due to maternal factors or perinatal events. alloimune thrombocytopenia, although underdiagnosed, is the most frequent type of severe thrombocytopenia in a term and otherwise healthy newborn, resulting from an immune mediated destruction of foetal/neonatal platelets by maternal alloantibodies. case report: we present the case of a newborn with alloimune thrombocytopenia, a typical clinical presentation and good outcome, highlighting the positive impact in the prognosis of a high index of suspicion and of empirical treatment with hpa-1a negative platelets. conclusion: an early diagnosis of this entity allows effective treatment with the infusion of compatible platelets, preventing eventual complications, namely intracranial haemorrhage. also guides the monitoring of future pregnancies and antenatal treatment.
%K alloimune thrombocytopenia
%K hpa-1a negative platelets
%K term newborn.
%U http://www.scielo.gpeari.mctes.pt/scielo.php?script=sci_abstract&pid=S0872-07542011000100004&lng=en&nrm=iso&tlng=en