%0 Journal Article
%T Effect of a hyperlipidic diet rich in omegas 3, 6 and 9 on aberrant crypt formation in rat colonic mucosa
%A Burlamaqui
%A Id¨¢lia Maria Brasil
%A Dornelas
%A Concei£¿£¿o Aparecida
%A Valen£¿a J¨²nior
%A Jos¨¦ Telmo
%A Mota
%A Daniel Magalh£¿es Coutinho
%A Mesquita
%A Francisco Jos¨¦ Cabral
%A Veras
%A Lara Burlamaqui
%A Vasconcelos
%A Paulo Roberto Leit£¿o
%A Rodrigues
%A Lusmar Veras
%J Acta Cirurgica Brasileira
%D 2012
%I Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
%R 10.1590/S0102-86502012000100006
%X purpose: to determine whether a hypercaloric and hyperlipidic diet enriched with polyunsaturated fatty acids influences the formation of aberrant crypt foci (acf) in colonic mucosa of wistar rats treated with azoxymethane (aom). methods: at eight weeks of life, the rats were assigned to four groups: group i¨Dstandard diet (std) not treated with aom; group ii¨Dhypercaloric and hyperlipidic diet (fed), not treated with aom; group iii¨Dstd, treated with aom; group iv¨Dfed, treated with aom. at 16 weeks, the animals were injected intraperitoneal with 0.9% saline solution (group i and ii) or aom at 15mg/kg (groups iii and iv) once a week for two weeks. fifteen weeks later, the animals were euthanized. results: fed promoted weight gain in groups ii and iv compared to groups i and iii, respectively. the groups did not differ with regard to the total number of acf. the chi-square test revealed no predominance of the presence of foci with <4 crypts. however, foci with ¡Ý5 crypts were proportionally more prevalent in group iii than in group iv (p=0.043). conclusion: the administration of polyunsaturated fatty acids did not interfere with the formation of aberrant crypt foci, but reduced acf multiplicity, exercising an attenuating effect on carcinogenesis.
%K dietary fats
%K unsaturated
%K azoxymethane
%K colorectal neoplasms
%K aberrant crypt foci. rats.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502012000100006&lng=en&nrm=iso&tlng=en