%0 Journal Article
%T Proliferative effect of aqueous extract of Hyptis fructicosa on liver regeneration after partial hepatectomy in rats
%A Lima
%A S£¿nia Oliveira
%A Viana
%A Luciano da Costa
%A Santana
%A F¨¢bio Rafael Teixeira de
%A Zucoloto
%A S¨¦gio
%A Albuquerque Junior
%A Ricardo Luiz de
%A Gomes
%A Margarete Zanardo
%J Acta Cirurgica Brasileira
%D 2012
%I Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
%R 10.1590/S0102-86502012000100012
%X purpose: to evaluate the effect of aqueous extract of hyptis fructicosa on hepatic regeneration after partial hepatectomy in rats. methods: sixteen rats were divided in two groups: c (control group) and hf (whose rats received aqueous extract of hyptis fructicosa during 4 days using the dose of 100 mg/kg/day). on the consecutive day of this treatment, the animals of both groups underwent hepatectomy of about 67% of liver. twenty four hours later, they were sacrificed, and the remaining mass of liver was removed and prepared to be studied through the pcna immunohistochemical technique. results: the liver regeneration index of hf group was 53.56 ¡À 18.91%, while in c group was 21.12 ¡À 8.29% (p=0.0003). conclusion: these results show that the administration of aqueous extract of hyptis fructicosa using the dose of 100mg/kg/day increased the hepatocyte proliferation in the group hf.
%K plants
%K medicinal
%K hepatectomy
%K proliferating cell nuclear antigen
%K liver regeneration
%K hyptis
%K rats.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502012000100012&lng=en&nrm=iso&tlng=en