%0 Journal Article
%T Effects of controlled and pressure support mechanical ventilation on rat diaphragm muscle
%A Oliveira
%A Andr¨¦ de S¨¢ Braga
%A Costa
%A L¨ªvia Bandeira
%A Assis
%A Thiago de Oliveira
%A Mota
%A Di¨®genes Lu¨ªs da
%A Fran£¿a
%A Eduardo ¨¦riko Ten¨®rio de
%A Ara¨²jo Filho
%A Jos¨¦ Candido de
%A Rosas
%A Silvania Tavares Paz
%A Medeiros
%A Paloma Lys de
%J Acta Cirurgica Brasileira
%D 2012
%I Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
%R 10.1590/S0102-86502012000200003
%X purpose: the objective of this study was to analyze the effects of pressure controlled ventilation mode (pcv-c) and psv mode in diaphragm muscle of rats. methods: wistar rats (n=18) were randomly assigned to the control group or to receive 6 hours of pcv and psv. after this period, animals were euthanized and their diaphragms were excised, frozen in liquid nitrogen and stored in at -80o c for further histomorphometric analysis. results: results showed a 15% decrease in cross-sectional area of muscle fibers on the pcv-c group when compared to the control group (p<0.001) and by 10% when compared to the psv group (p<0.05). minor diameter was decreased in pcv-c group by 9% when compared with the control group (p<0.001) and by 6% when compared to the psv group (p<0.05). when myonuclear area was analyzed, a 16% decrease was observed in the pcv-c group when compared to the psv group (p<0.05). no significant difference between the groups was observed in myonuclear perimeter (p>0.05). conclusion: short-term controlled mechanical ventilation seems to lead to muscular atrophy in diaphragm fibers. the psv mode may attenuate the effects of vidd.
%K anatomy & histology
%K diaphragm
%K tracheostomy
%K rats
%K wistar.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502012000200003&lng=en&nrm=iso&tlng=en