%0 Journal Article
%T Intestinal healing in rats submitted to ethanol ingestion
%A Pereira
%A Rodrigo Severo de Camargo
%A Hasimoto
%A Cl¨˘udia Nishida
%A Pelafsky
%A Leonardo
%A Llanos
%A Juan Carlos
%A Cataneo
%A Daniele Cristina
%A Spadella
%A C¨¦sar Tadeu
%A Minossi
%A Jos¨¦ Guilherme
%J Acta Cirurgica Brasileira
%D 2012
%I Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
%R 10.1590/S0102-86502012000300006
%X purpose: to study the effect of alcoholism on intestinal healing and postoperative complications in rats methods: one hundred and sixty rats were divided into two groups: control and treated. the control group received water and the treated group 30% ethanol. after 180 days, colotomy with anastomosis were performed. after, the groups were divided into four subgroups: 20 rats for study at the following moments: 4th, 7th, 14th and 21st postoperative. the analyzed parameters were: weight gain, breaking strength, tissue hydroxyproline, postoperative complications and histopathological study results: weight gain was greater in the control group (p<0.05). when all the subgroups were clustered, breaking strength was significantly greater in the control (p<0.05). histopathology and hydroxyproline dosage did not show differences. there were five surgical site infections in the treated group while the control group showed two (p>0.05). nine fistulas occurred in the treated group whereas the control group two (p<0.05). there were three deaths in the control group and seven in the treated group (p>0.05). conclusions: treated group undergo a malnutrition process that is revealed by lower weight gain. impaired intestinal healing as indicated by smaller breaking strength. there were a larger number of postoperative complications in the treated animals.
%K wound healing
%K alcoholism
%K ethanol
%K tensile strenght
%K hydroxyproline
%K rats.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502012000300006&lng=en&nrm=iso&tlng=en