%0 Journal Article
%T Association of mesenchymal stem cells with platelet rich plasma on the repair of critical calvarial defects in mice
%A Monteiro
%A Betania Souza
%A Del Carlo
%A Ricardo Junqueira
%A ArgŁżlo-Neto
%A NapoleŁżo Martins
%A Nardi
%A Nance Beyer
%A Carvalho
%A Pablo Herthel
%A Bonf¨˘
%A Laila de Paula
%A Chagastelles
%A Pedro C¨¦sar
%A Moreira
%A Higo Nasser
%A Viloria
%A Marlene Isabel Vargas
%A Santos
%A Bianka Souza dos
%J Acta Cirurgica Brasileira
%D 2012
%I Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
%R 10.1590/S0102-86502012000300001
%X purpose: to evaluate the effects of mesenchymal stem cells (msc) from eight mice c57bl/6 gfp+ bone marrows expanded in cultures associated with platelets rich plasma (prp) deriving from another eight mice, in the repair of critical defects in calvarial bone produced in twenty-four adult isogenic mice c57bl/6. methods: the animals were submitted to a cranial defect of 6.0mm in diameter and divided into two equal experimental groups. control group did not receive treatment and the treated group received a msc pellet containing 1.0 x 107 cells/ml associated with 50.0¦Ěl of plasma gel containing 1.0 x 109 autologous platelets within the defect. results: in the treated group was observed process of angiogenesis and bone repair better than control group. conclusion: mesenchymal stem cells derived from bone marrow of c57bl/6 gfp+ mice associated with prp gel applied in bone critical defects produced in calvarial contributes positively to the process of bone repair.
%K mesenchymal stem cells
%K platelet-rich plasma
%K tissue therapy
%K skull
%K mice.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502012000300001&lng=en&nrm=iso&tlng=en