%0 Journal Article
%T Beneficial effect of ubiquinol, the reduced form of coenzyme Q10, on cyclosporine nephrotoxicity
%A Ishikawa
%A Akira
%A Homma
%A Yukio
%J International braz j urol
%D 2012
%I Sociedade Brasileira de Urologia
%R 10.1590/S1677-55382012000200011
%X background: cyclosporine (cya) nephrotoxicity is partly due to some oxidative stress. ubiquinol, the reduced form of coenzyme q10 (rcoq10), has recently gained attention for its anti-oxidative potential. the aim of this study is to evaluate the effect of rcoq10 on a cya nephrotoxic rat model. materials and methods: six-week-old male wistar rats were divided into three groups (five animals each). group 1 received a medium only. group 2 received 30 mg/kg/day of cya only. group 3 received both the same dose of cya and 600 mg/kg/day of rcoq10. cya and rcoq10 were both given orally for four weeks. systolic blood pressure (bp), daily urinary albumin secretion (u-alb), serum creatinine (s-cr) level, and super-oxide anion (so) level in the renal tissue were measured and compared among those three groups. immunohistochemistry using an antibody for the transforming growth factor-beta (tgf-beta) was also examined. results: bps, u-albs, s-crs, and so levels of groups 1, 2, and 3 were 114 ¡À 3, 132 ¡À 4, and 129 ¡À 5 mmhg, 2.6 ¡À 0.5, 42.1 ¡À 7.2, and 22.8 ¡À 3.4 micro-g/day, 1.1 ¡À 0.2, 1.7 ¡À 0.2, and 1.3 ¡À 0.2 mg/dl, and 224 ¡À 84, 1251 ¡À 138, and 512 ¡À 109 rlu/g kidney respectively. u-albs, s-crs, and so levels were significantly ameliorated by rcoq10. micro-vacuolar changes and tgf-beta positive deposits in the proximal renal tubular cells of cya group rats disappeared in those of cya and rcoq10 group rats. conclusion: rcoq10, an antioxidants, may have potential for preventing cya nephrotoxicity.
%K oxidative stress
%K antioxidants
%K cyclosporine
%K transforming growth factor-beta.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1677-55382012000200011&lng=en&nrm=iso&tlng=en