%0 Journal Article
%T Posible papel de Bacteroides fragilis enterotoxig¨¦nico en la etiolog¨ªa de la vaginitis infecciosa
%A Polanco
%A Nina
%A Manzi
%A Lorna
%A Carmona
%A Oswaldo
%J Investigaci¨®n Cl¨ªnica
%D 2012
%I Scientific Electronic Library Online
%X vaginitis is a common gynecologic disorder. it is due to several causes, some even unknown. bacteroides fragilis is the most important anaerobe in clinical bacteriology, some strains of this group are notable for being enterotoxigenic and they have been associated with intestinal and extraintestinal syndromes. they have recently been isolated from patients with vaginitis. the purpose of this study was to investigate a possible association of enterotoxigenic b. fragilis with infectious vaginitis. 265 samples of vaginal exudate were processed, 202 from symptomatic patients and 63 healthy women. the identification of the microorganisms was carried out by conventional methods. in 31.2% of symptomatic patients were identified: gardnerella vaginalis, mobiluncus, candida albicans, mycoplasma hominis, ureaplasma urealyticum and streptococcus agalactiae. b. fragilis was identified in 27 symptomatic patients and 5 healthy women. these strains were cultivated in liquid medium and incubated during 48 h at 36¡ãc in anaerobe chambers. supernatant activity was assayed in ht-29 cells. eighteen b. fragilis strains isolated from symptomatic patients were enterotoxigenic, because induced alterations in target cell morphology. it was not identified in healthy women (p<0.05). 77.7% of enterotoxigenic b. fragilis strains were not associated with other specific pathogens. this fact suggests that enterotoxigenic b. fragilis could be a cause for vaginitis. the effect of enterotoxin on e-cadherin of vaginal epithelium could facilitate invasion and its possible pathogenic role in the vagina. this is the first report that associates enterotoxigenic bacteroides fragilis as a possible cause of infectious vaginitis.
%K vaginitis
%K mixed infection
%K enterotoxigenic bacteroides fragilis
%K ht-29 cells.
%U http://www.scielo.org.ve/scielo.php?script=sci_abstract&pid=S0535-51332012000100004&lng=en&nrm=iso&tlng=en